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Article type: Research Article
Authors: Liu, Yuhana; 1 | Zhang, Juanb; 1 | Xing, Cuihongc | Wei, Shuxind | Guo, Nae | Wang, Yanlif; *
Affiliations: [a] The First Department of Orthopedics, Qingdao West Coast New Area Central Hospital, Qingdao, Shandong, China | [b] Outpatient Department, Yantai Yeda Hospital, Yantai, Shandong, China | [c] Department of Internal Medicine Ward, The People’s Hospital of Zhangqiu Area, Jinan, Shandong, China | [d] Department of Anesthesiology, The People’s Hospital of Zhangqiu Area, Jinan, Shandong, China | [e] Department of Blood Transfusion, The People’s Hospital of Zhangqiu Area, Jinan, Shandong, China | [f] Department of Oncology, Jining No. 1 People’s Hospital, Jining, Shandong, China
Correspondence: [*] Corresponding author: Yanli Wang, Department of Oncology, Jining No. 1 People’s Hospital, 6 Jiankang Road, Jining 272000, Shandong, China. Tel.: +86 0537 2253104; E-mail: jh12077829y@163.com.
Note: [1] These authors contributed equally to this study and share first Authorship.
Abstract: OBJECTIVE: Osteosarcoma is the most common malignant tumor of bone with high recurrent rate. miR-486 was downregulated and acted as a tumor suppressor in plenty of tumors. The purpose of this study was to explore how miR-486 worked in osteosarcoma on cell invasion and EMT. RESULTS: miR-486 was low expressed in osteosarcoma while PIM1 was overexpressed, and it had negative correlation between miR-486 and PIM1. miR-486 upregulation or PIM1 downregulation could inhibit osteosarcoma cell invasion and EMT. Meanwhile, miR-486 mediated PIM1 expression through binding to PIM1 mRNA 3’-UTR. PIM1 could reveal partial function of miR-486 on osteosarcoma invasion. In addition, miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. CONCLUSION: miR-486 regulated osteosarcoma cell invasion and EMT through targeting to PIM1. miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. The newly identified miR-486/PIM1 axis provides novel insight into the pathogenesis of osteosarcoma.
Keywords: miR-486, PIM1, invasion, EMT, osteosarcoma
DOI: 10.3233/CBM-181527
Journal: Cancer Biomarkers, vol. 23, no. 2, pp. 269-277, 2018
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