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Article type: Research Article
Authors: Shen, Wenjiea; * | Cui, Ming-Mingb | Wang, Xinb | Wang, Rui-Taob; c; *
Affiliations: [a] Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China | [b] Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, Heilongjiang, China | [c] Heilongjiang Academy of Medical Science, Harbin 150081, Heilongjiang, China
Correspondence: [*] Corresponding authors: Wenjie Shen, Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, NO. 51 Fucheng road, Haidian district, Beijing 100048, China. Tel.: +86 010 66867076; Fax: +86 010 66867071; E-mail: 13552929646@163.com.Rui-TaoWang,DepartmentofInternalMedicine,HarbinMedicalUniversityCancerHospital,HarbinMedicalUniversity,NO.150HapingST,NangangDistrict,Harbin150081,Heilongjiang,China.Tel.:+8645186298352;Fax:+8645186298353;E-mail:ruitaowang@126.com.
Abstract: BACKGROUND: Esophageal cancer (EC) is the sixth most common cause of death from cancer. Altered mean platelet volume (MPV) levels were found in patients with malignancies. OBJECTIVE: The present study investigated whether MPV can predict the survival in EC patients. MEHTODS: The clinical data of 236 consecutive EC patients between January 2009 and December 2009 in our center were retrospectively analyzed. The overall survival rate was estimated using Kaplan-Meier method. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis. RESULTS: Decreased MPV was significantly correlated with tumor location and tumor differentiation (p< 0.001). Moreover, survival analysis revealed that the overall survival of patients with MPV ⩽ 7.4 fL was significantly shorter than that of those with MPV > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic factor for overall survival. CONCLUSIONS: Reduced MPV is associated with worse survival outcome in EC.
Keywords: Esophageal cancer, mean platelet volume, prognosis
DOI: 10.3233/CBM-181231
Journal: Cancer Biomarkers, vol. 22, no. 3, pp. 559-563, 2018
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