The emerging roles of long non-coding RNA in gallbladder cancer tumorigenesis

Article type: Research Article

Authors: Chen, Bing^{a; 1} | Li, Ya^{a; 1} | He, Yuting^b | Xue, Chen^b | Xu, Feng^{a; *}

Affiliations: [a] Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China | [b] Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

Correspondence: [*] Corresponding author: Feng Xu, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou 450052, Henan, China. E-mail: wheat1121@live.cn.

Note: [1] These authors contributed equally to this work.

Abstract: Accumulating evidence suggests that long non-coding RNAs (lncRNAs) have important regulatory functions in gallbladder cancer (GBC) tumorigenesis and can serve as potential novel markers and/or targets for GBC. In this review, we critically discuss the emerging alteration of lncRNAs in GBC, the lncRNAs induced epigenetic regulation, the interaction of lncRNAs with microRNAs and lncRNAs effects on tumor-related signaling pathways. Additionally, contributions of lncRNAs in epithelial-mesenchymal transition process and energy metabolism reprogramming in GBC are also addressed. This may pave new ways towards the determination of GBC pathogenesis and lead to the development of new preventive and therapeutic strategies for GBC.

Keywords: Long non-coding RNAs, gallbladder cancer, epigenetic regulation, microRNAs, tumor-related signaling pathways

DOI: 10.3233/CBM-170979

Journal: Cancer Biomarkers, vol. 22, no. 3, pp. 359-366, 2018