Clinical risk analysis of non-visualized sentinel lymph node in breast cancer
Article type: Research Article
Authors: Zhang, Jinga; b; c; d; e; 1 | Pei, Jingf; g; 1 | Liu, Honga; b; c; d; e; h; *
Affiliations: [a] Tianjin Medical University Cancer Institute and Hospital, Tianjin 300070, China | [b] National Clinical Research Center for Cancer, Tianjin 300070, China | [c] Key Laboratory of Cancer prevention and Therapy, Tianjin 300070, China | [d] Tianjin’s Clinical Research Center for Cancer, Tianjin 300070, China | [e] Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300070, China | [f] Department of Breast Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China | [g] Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China | [h] The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300070, China
Correspondence: [*] Correspondence author: Hong Liu, The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300070, China. Tel.: +86 18622221169; Fax: +86 022 23340123; E-mail: liuhong_lh332@163.com.
Note: [1] These authors contributed equally to this work and should be considered co-first authors.
Abstract: OBJECTIVE: This study aimed to explore the positive rate of non-visualized sentinel lymph nodes (non-vSLN) [1] in breast cancer (BC) patients and the discrepancy of non-vSLN among different molecular subtypes, in order to further evaluate the clinical risk of non-vSLNs. METHODS: A total of 627 patients were retrospectively analyzed. These patients were pathologically confirmed with invasive breast cancer and underwent sentinel lymph node biopsy (SLNB). Various factors were compared using chi-square test. The positive rate of SLNs between non-vSLNs and visible sentinel lymph nodes (vSLNs) were compared. Moreover, factors that influenced the prognosis, such as ER, PR, HER-2, histological grade and lymph node metastasis were compared between these two groups. RESULTS: Among the 627 patients who underwent SLNB, 196 patients had non-vSLNs, accounting for 31.26% (196/627) and 113 patients had positive SLNs, accounting for 18.02% (113/627). Furthermore, 40.71% (46/113) of patients with positive SLNs had non-vSLN, and 17.39% (8/46) of patients with non-vSLN had HER-2+BC. In contrast, 35.82% (24/67) of patients with vSLNs had HER-2+BC. Moreover, 23.91% (11/46) of patients with non-vSLN and 5.97% (4/67) of patients with vSLNs had triple-negative breast cancer (TNBC). The metastasis rate was 41.30% (19/46) in the non-vSLN group and 43.28% (29/67) in the vSLN group. The difference in the rate of positive SLNs between the non-vSLN and the vSLN groups was statistically significant (P< 0.05), in which the positive rate of SLNs in the non-vSLN group was remarkably higher than that in the vSLN group. The differences in the proportion of HER-2+BC and TNBC between the non-vSLN and the vSLN groups were statistically significant (P< 0.05), in which HER-2+BCwas evidently higher in the vSLN group than in the non-vSLN group. Meanwhile, TNBC was markedly higher in non-vSLN group than in the vSLN group. Furthermore, differences in Luminal A subtype, Luminal B subtype and non-SLN metastasis between these two groups was not statistically significant. In addition, the difference in non-SLN metastasis rate was not statistically significant among breast cancers of different molecular subtypes and between the non-vSLN and the vSLN groups. CONCLUSION: Breast cancer patients with positive non-vSLNs are more likely to have a TNBC subtype relative to patients with positive vSLN. Breast cancer patients with non-vSLN have higher positive rate of SLNs. The non-SLN metastasis rate in positive SLN patients was not correlated to the molecular subtype of breast cancer.
Keywords: Breast cancer, non-visible, sentinel lymph node, risk analysis, molecular subtype
DOI: 10.3233/CBM-170958
Journal: Cancer Biomarkers, vol. 23, no. 2, pp. 179-183, 2018
