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Article type: Research Article
Authors: Trojani, Alessandraa; * | Pungolino, Estera | Rossi, Giuseppeb | D’Adda, Mariellab | Lodola, Milenaa | Camillo, Barbara Dic | Perego, Alessandrad | Turrini, Mauroe | Orlandi, Esterf | Borin, Lorenzag | Iurlo, Alessandrah | Malato, Simonai | Spina, Francescoj | Latargia, Maria Luisak | Lanza, Francescol | Artale, Salvatorem | Anghilieri, Michelan | Carraro, Maria Cristinao | Canal, Gabriella Dep | Morra, Enricaq | Cairoli, Robertoa
Affiliations: [a] Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy | [b] Department of Hematology, ASST Spedali Civili, Brescia, Italy | [c] Department of Information Engineering, University of Padova, Padova, Italy | [d] Internal Medicine-Haematology, Desio Hospital, Desio, Italy | [e] Division of Hematology, Department of Internal Medicine, Valduce Hospital, Como, Italy | [f] Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy | [g] Hematology Division, San Gerardo Hospital, Monza, Italy | [h] Oncohematology Division, IRCCS Ca’ Granda – Maggiore Policlinico Hospital Foundation, Milano, Italy | [i] Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano, Italy | [j] Division of Hematology – Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy | [k] ASST Valle Olona Ospedale di Circolo, Busto Arsizio, Italy | [l] Division of Hematology, Hospital of Cremona, Cremona, Italy | [m] ASST Valle Olona Sant’Antonio Abate, Gallarate, Italy | [n] ASST Lecco, Lecco, Italy | [o] Hematology and Transfusion Medicine, Sacco Hospital, Milano, Italy | [p] Pathology Department, Cytogenetics, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy | [q] Executive Committee, Rete Ematologia Lombarda, Italy
Correspondence: [*] Corresponding author: Alessandra Trojani, Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy. Tel.: +39 2 64442711; Fax: +39 2 64447598; E-mail: alessandra.trojani@ospedaleniguarda.it.
Abstract: BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined. OBJECTIVE: We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin- cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions.
DOI: 10.3233/CBM-170209
Journal: Cancer Biomarkers, vol. 21, no. 1, pp. 41-53, 2018
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