Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Liu, Jiaxiua; * | Xu, Binb | Xu, Guoyinga | Zhang, Xiaoleia | Yang, Xueyia | Wang, Jiandongc
Affiliations: [a] Department of Molecular Biology, Jiangsu College of Nursing, Huaian 223300, Jiangsu, China | [b] Jiangsu Huaian Third People’s Hospital, Huaian 223340, Jiangsu, China | [c] Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, Jiangsu, China
Correspondence: [*] Corresponding author: Jiaxiu Liu, Department of Molecular Biology, Jiangsu College of Nursing, Huaian 223300, Jiangsu, China. E-mail: ljx9254@163.com.
Abstract: BACKGROUND: Eph receptors comprise the largest group of the receptor tyrosine kinase (RTK) family, and Eph receptors interacting with their ligand ephrins play an important role in development and tumorigenesis. EphB6, a special Eph receptor that lacks tyrosine kinase activity, was reported to be expressed in some human cancers. The clinical significance of EphB6 in gastric carcinoma has not been well investigated. METHODS: In this study, we detected expression of EphB6 protein in four gastric cancer cell lines and a set of gastric carcinoma tissue specimens by using immunohistochemistry. The relationship between EphB6 protein expression and clinicopathological parameters was statistically analyzed. RESULTS: EphB6 protein was differentially detected in four gastric cancer cell lines. EphB6 protein was low expressed in 52.6%, moderately expressed in 32.59%, and strongly expressed in 14.5% of gastric carcinomas. EphB6 expression was positively associated with tumor differentiation (P< 0.001, rs= 0.476), and negatively associated with lymph node metastasis (P< 0.001, rs=-0.444) and tumor stage (P= 0.001, rs=-0.269). Low EphB6 expression was detected more often in female patients (P= 0.031). No significant relationship between EphB6 expression and patient age, tumor location, or depth of tumor invasion was identified. CONCLUSION: Our data indicate that EphB6 protein was decreased in gastric carcinoma compared with normal mucosa. Analytic results based on pathological parameters suggests that EphB6 protein may inhibit metastasis of gastric carcinoma and could be a potential therapeutic target for gastric carcinoma.
Keywords: EphB6, receptor tyrosine kinase, gastric carcinoma
DOI: 10.3233/CBM-160256
Journal: Cancer Biomarkers, vol. 19, no. 3, pp. 241-248, 2017
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl