Affiliations: [a] Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt | [b] Clinical and Chemical Pathology Department, National Cancer Institute, Cairo University, Giza, Egypt
Correspondence:
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Corresponding author: Shahira Kamal Anis Botros, Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, 26 Atbara st. Agouza, Giza 12411, Egypt. Tel.: +20 1223780160; Fax: +20 233028545; E-mail:shahirabotros75@outlook.com
Abstract: OBJECTIVE: Multiple genetic alterations with prognostic significance have been
discovered in acute myeloid leukemia (AML). We studied the expression level
of two genes, Meningioma1 (MN1) and Phosphatase and Tensin homolog (PTEN)
to determine their expression in AML patients and their role as prognostic
markers. METHODS: The study included 50 cytogenetic normal de novo AML cases and 10
controls, Their level was detected by Real time Reverse
Transcription-Polymerase Chain Reaction. RESULT: Relative mRNA expression of MN1 was significantly higher (p value < 0.001)
and PTEN expression was significantly lower (p value = 0.002). No
correlation was found between neither MN1 nor PTEN mRNA expression and
overall survival (p value = 0.212 and 0.310) respectively. CONCLUSION: Although our study suggests a role for MN1 gene and PTEN genes in AML, we
could not recommend their use as routine diagnostic and prognostic markers
for AML in Egyptian population.
