Affiliations: [a] Department of Hematology, Fujian Provincial Hospital, Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China | [b] Department of Pathology, Fujian Provincial Hospital, Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China
Correspondence:
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Corresponding author: Wei-Ming Chen, Department of Hematology, Fujian Provincial Hospital, Provincial Clinical Medical College of Fujian Medical University, 134 Dong Jie, Fuzhou 350001, Fujian, China. Tel.: +86 591 8755 7768; Fax: +86 591 8755 7768; E-mail:chenwmpaper@sina.com
Abstract: BACKGROUND: Peripheral T-cell lymphoma, not otherwise specified
(PTCL-NOS) is an obviously heterogeneous and highly invasive malignancy
without definite phenotype. MicroRNAs (miRNAs) are powerful gene regulators
and have been reported as biomarkers in many malignancies. OBJECTIVE: To discover potential signaling miRNAs in PTCL-NOS
distinguished from reactive lymphoid hyperplasia (RLH) and to explore the
molecular characteristics based on the discovery. METHODS: We measured the expression profile of miRNAs in PTCL-NOS
and RLH from our patients using a panel PCR array. We used GO-Analysis to
evaluate the function of the targets regulated by the detected miRNAs. Then
using pathway enrichment analysis, we defined potential pathways connected
with the selected miRNAs. RESULTS: We found 20 miRNAs which were remarkably up/down-regulated
in PTCL-NOS. GO-Analysis and pathway analysis indicated 61 GOs and 34
signaling pathways that were significantly increased or decreased regarding
tumorigenesis, tumor progression, invasion, metastasis, and drug resistance. CONCLUSIONS: Briefly, our results suggest that 20 miRNAs have the
potential to be used as biomarker for identification of patients with
PTCL-NOS.
Keywords: Peripheral T-cell lymphoma, microRNA, profiling, tumorigenesis, drug resistance
