The Pin1 gene polymorphism and the susceptibility of oral squamous cell carcinoma in East China

Article type: Research Article

Authors: Yao, Jie^{a; b} | Wang, Jian-Ming^c | Wang, Zi-Lu^b | Wu, Yu-Nong^{a; *}

Affiliations: [a] Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China | [b] Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China | [c] Department of Epidemiology and Biostatistics, Faculty of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China

Correspondence: [*] Corresponding authors: Yu-Nong Wu and Zi-Lu Wang, No. 136 Hanzhong Avenue, Nanjing, Jiangsu 210029, China. Tel.: +86 25 8503 1871; Fax: +86 25 8651 6414; E-mail: wynoms@gmail.com.

Abstract: Pin1 is a peptidylprolyl isomerase that specifically recognizes phosphorylated Pro-directed Ser/Thr (pSer/Thr-Pro) peptide sequences. Genetic variants in the Pin1 gene may alter protein function and cancer risk. In this study, we genotyped the two common promoter polymorphisms -842G/C (rs2233678) and -667T/C (rs2233679) in two independent hospital-based case-control studies conducted in Eastern Chinese populations, including 209 patients with oral squamous cell carcinoma and 444 cancer-free controls. We found -667TT heterozygotes had a significantly increased risk of oral squamous cell carcinoma (P=0.028, OR=1.66, 95%CI=1.02–2.69). However, there was no risk significant associated with the -842G/C polymorphism. Further large population-based studies are needed to confirm these results.

Keywords: Polymorphism, single nucleotide (SNP), peptidylprolyl isomerase pin1, oral squamous cell carcinoma (OSCC)

DOI: 10.3233/CBM-140421

Journal: Cancer Biomarkers, vol. 14, no. 6, pp. 441-447, 2014