Affiliations: [a] Department of Microbiology and Immunology, Medical College of Southeast University, Nanjing, Jiangsu, China | [b] Department of General Surgery, Zhongda Hospital, Southeast University Medical School, Nanjing, Jiangsu, China | [c] Women and Infants Hospital of Zhengzhou, Zhengzhou, Henan, China
Correspondence:
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Corresponding author: Xueren Gao, Department of Microbiology and Immunology, Medical College of Southeast University, Nanjing, Jiangsu 210009, China. E-mail: gxr871230@126.com.
Note: [1]
These authors contributed equally to this work.
Abstract: Background:Associations between cytotoxic T lymphocyte antigen-4 (CTLA-4) +49A/G polymorphism and cancer risk are inconclusive. We performed this meta-analysis to derive a more precise estimation of the relationship. Methods:A comprehensive literature search was performed using electronic databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results:A total of 16,358 cases and 19,737 controls from 46 studies were included. Overall, significant association between CTLA-4 +49A/G polymorphism and cancer risk was observed in all genetic models (G vs. A: OR=0.88, 95%CI=0.83–0.93, PH=0.000; GA vs. AA: OR=0.87, 95%CI=0.79–0.97, PH=0.000; GG vs. AA: OR=0.75, 95%CI= 0.65–0.86, PH=0.000; GG vs. GA+AA: OR=0.84, 95%CI=0.79–0.91, PH=0.001; GG+GA vs. AA: OR=0.83, 95%CI=0.74–0.92, PH=0.000). Stratified analysis by cancer type revealed that the CTLA-4+49A/G polymorphism is associated with the decreased risk of cervical cancer, breast cancer, lung cancer, HCC. Further subgroup analysis by ethnicity indicated that there was a statistically decreased cancer risk in Asian population. Conclusion:This meta-analysis suggests that CTLA-4+49A/G polymorphism is associated with cancer risk, especially in Asian population.
Keywords: \CTLA-4, polymorphism, cancer risk, meta-analysis
