Affiliations: [a] Department of Otolaryngology, Lütfiye Nuri Burat State Hospital, Istanbul, Turkey | [b] Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey | [c] Department of Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey
Correspondence:
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Corresponding author: Özgür Sürmelioǧlu, Department of Otolaryngology, Faculty of Medicine, Çukurova University, Adana, Turkey. Gsm: +90 5376511501; E-mail: Surmeli2004@yahoo.com.
Abstract: Background:The general prognostic factors in larynx tumors are believed to be tumor stage, anatomical location, histological differentiation and the presence of neck metastasis. Effects of tumor invasion to sub-regions of larynx (anterior commissure, ventricle, subglottic space) and over-expression of p53, c-erb-B2 and Ki67 detected immunohistochemically on development of recurrence in patients were investigated in this study. Methods:Twenty patients (Group 1) in whom recurrence had developed and 20 others (Group 2) without recurrence during follow-up were included in this study. Results:Both the anterior commissure and ventricle involvements were found to be more frequent in patients with recurrence. But statistically significant difference was detected with only ventricular involvement (p=0.025). After Immunohistochemical evaluation none of the 3 immunohistochemical parameters were found to be higher in the recurrence group and not any of them showed a statistically significant difference between two groups. Conclusion:Only ventricle involvement may be a predictor factor for recurrence.
