Affiliations: [a] Department of Oncology, Affiliated Hospital of Guiyang Medical College, and Guizhou Cancer Hospital, Guizhou, China | [b] Central laboratory of Molecular Biology, Guiyang Medical University, Guizhou, China
Correspondence:
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Corresponding author: Wenling Wang, Department of Oncology, Affiliated Hospital of Guiyang Medical College, and Guizhou Cancer Hospital 510000, Guizhou, China. Tel.: +86 0851 6812999; Fax: +86 0851 6812999; E-mail: wenlingwang798@163.com.
Abstract: Objective:To investigate the relationship between telomerase activity (TA) and matrix metallo proteinases 2 (MMP-2) on malignant behavior and prognosis predictable value in gastric cancer. Methods:Telomerase activity and MMP-2 protein expressions were tested in 40 gastric surgical resected cancer samples and the clinicopathological data of enrolled patients were obtained to get correlation analysis results. Results:The expression of telomerase was up-regulated with infiltrating depth, lymph node metastasis and stage (P< 0.01). Positive expression rate of MMP-2 in gastric cancer tissues was 44.35%, negative in normal gastric tissues. Multivariate analysis of Logistic regression showed telomerase activity and MMP-2 expression were hazardous makers correlated with infiltrating depth (P< 0.05). Conclusion:Combined detections of telomerase activity and MMP2 protein could identify patients at high risk in disease recurrence and prognosis more efficiently.
