Tumor vascular biomarkers: New opportunities for cancer diagnostics¹

Issue title: Biomarkers for Ovarian Cancer: New Technologies and Targets to Address Persistently Unmet Needs

Guest editors: Michael A. Tainskyx and Anna Lokshiny

Article type: Research Article

Authors: Li, Chunsheng^a | Sasaroli, Dimitra^a | Chen, Xiang^a | Hu, Jia^a | Sandaltzopoulos, Raphael^b | Omidi, Yadolah^a | Coukos, George^{a; *}

Affiliations: [a] Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA | [b] Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece | [x] Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI, USA | [y] University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA, USA

Correspondence: [*] Corresponding author: George Coukos, E-mail: gcks@mail.med.upenn.edu.

Note: [1] Equal contribution.

Abstract: Tumor vasculature varies significantly from its normal counterpart and displays unique markers. Recent technological advancements including immunohistochemistry laser-capture microdissection (immuno-LCM), genome-wide high-throughput screening, and proteomics have uncovered a vast array of vascular bed-specific markers that may provide a platform for discovery of new therapeutics directed against various malignancies. However, an essential step in the translation of these markers to clinical application will be the identification of those biomarkers with the highest diagnostic and therapeutic potential. The aim of the current review is to provide a synopsis of recent advancements in the identification of tumor vasculature biomarkers.

DOI: 10.3233/CBM-2011-0217

Journal: Cancer Biomarkers, vol. 8, no. 4-5, pp. 253-271, 2011