Affiliations: [a]
Oncology Department, Bogomolets National Medical University, 03022, Kyiv, Ukraine
| [b] Chiltern Clinical Research Ukraine LLC, Department of Statistics and Demography, Taras Schevchenko National University of Kyiv, Kyiv, Ukraine
| [c]
Oncology Department Bogomolets National Medical University, 03022, Kyiv, Ukraine
Correspondence:
[*]
Corresponding author: Igor Motuzyuk. Oncology Department Bogomolets National Medical University, 03022, 33/43 Lomonosova Street, Kyiv, Ukraine. Tel.: +38 067 719 99 22. E-mail: 180978igor@gmail.com
Abstract: AIM:This study aims to describe the current state of multiple primary malignant neoplasms (MPMNs) breast cancer patients management, evaluate the predictive impact of different factors, optimise approaches to diagnosis and treatment of these patients and improve their life quality. METHODS:The study included 2,032 patients who received special treatment at the Department of Breast Tumours and it Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 within an open randomized controlled trial. The sample included 195 patients with synchronous cancer or metachronous breast cancer. RESULTS:A more aggressive course of breast cancer is observed in patients exposed to radiation from the Chornobyl accident. The clinical course of disease in patients with synchronous breast cancer is worse and prognostically unfavourable comparing to metachronous one. The influence on clinical course of disease of primary localization, type of settlement, blood group and Rh factor, type of special treatment, and age in patients with synchronous and metachronous cancer was not statistically proven. The impact of operative intervention scope in patients with synchronous and metachronous breast cancer was statistically proven, i.e. the course of the underlying disease in patients who underwent mastectomy is worse comparing to patients who underwent conservative surgery. Plastic and reconstructive surgery in patients with synchronous cancer was statistically proven in this study as reasonable. The influence of local recurrence rates on overall survival in patients with synchronous cancer was proven. However, the influence of local recurrence rates in patients with metachronous cancer was not statistically proven. CONCLUSIONS:There should be paid a great attention to synchronous and metachronous breast cancer patients in order to find and provide the best options of their management. This is crucial to continue researches in this field of oncology.
Keywords: multiple primary malignant neoplasms (MPMNs), synchronous and metachronous breast cancer, Chornobyl accident.
DOI: 10.3233/BD-170285
Journal: Breast Disease, vol. 37, no. 2, pp. 83-93, 2017
