Ginger potency on the prevention and treatment of breast cancer

Article type: Review Article

Authors: Usman, Andi Nilawati^a; | Manju, Budu^b | Ilhamuddin, Ilhamuddin^b | Ahmad, Mardiana^a | AB, Takko^c | Ariyandy, Andi^b | Budiaman, Budiaman^d | Eragradini, Athirah Rinandha^e | Hasan, Intan Idiana^f | Hashim, Sabarisah^g | Sartini, Sartini^h | Sinrang, Andi Wardihan^{a; b}

Affiliations: [a] Department of Midwifery, Graduate School, Hasanuddin University, Makassar, Indonesia | [b] Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [c] Cultural Science, Hasanuddin University, Makassar, Indonesia | [d] Department of Forestry, Hasanuddin University, Makassar, Indonesia | [e] Graduate School, Hasanuddin University, Makassar, Indonesia | [f] Nursing and Midwifery, Universiti Sains Malaysia, Malaysia | [g] Neurosciences, Universiti Sains Malaysia, Indonesia | [h] Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

Correspondence: [*] Corresponding author: Andi Nilawati Usman, Department of Midwifery, Graduate School, Hasanuddin University, Makassar, Indonesia. Tel.: +6285255990153; E-mail: andinilawati@pasca.unhas.ac.id

Abstract: BACKGROUND:Cancer is a type of disease caused by the uncontrolled growth of abnormal cells that can destroy body tissues. The use of traditional medicine naturally uses plants from ginger with the maceration method. The ginger plant is a herbaceous flowering plant with the Zingiberaceacea group. METHODS:This study uses the literature review method by reviewing 50 articles from journals and databases. RESULTS:A review of several articles, namely ginger has bioactive components such as gingerol. Ginger is used as a treatment in complementary therapies using plants. Ginger is a strategy with many benefits and functions as a nutritional complement to the body. This benefit has shown the effect of anti-inflammatory, antioxidant, and anticancer against nausea and vomiting due to chemotherapy in breast cancer. CONCLUSION:Anticancer in ginger is shown by polyphenols associated with anti-metastatic, anti-proliferative, antiangiogenic, anti-inflammatory, cell cycle arrest, apoptosis, and autophagy. Therefore, consuming ginger regularly affects natural herbal therapy with the prevention and treatment of breast cancer and serves as a prevention against the effects of chemotherapy.

Keywords: Ginger, prevention, treatment, cancer, breast

DOI: 10.3233/BD-239003

Journal: Breast Disease, vol. 42, no. 1, pp. 207-212, 2023