Affiliations: [a] Department of Midwifery, Graduate School, Hasanuddin University, Makassar, Indonesia | [b] Department of Anthropology, Hasanuddin University, Makassar, Indonesia | [c] Graduate School, Hasanuddin University, Makassar, Indonesia | [d] Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [e] School of Health Science, Universiti Sains, Kelantan, Malaysia | [f] Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
Correspondence:
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Corresponding author: Andi Nilawati Usman, Department of Midwifery, Graduate School, Hasanuddin University, Makassar, Indonesia. Tel.: +62 85240093168; E-mail: andinilawati@pasca.unhas.ac.id
Abstract: BACKGROUND:FOXP3 Tregs have been found in breast cancer patients, both humoral and tumor. Survival or prognosis of breast cancer patients seems to correlate with the increase and decrease in FOXP3 Treg. OBJECTIVES:This review aims to provide insights regarding the FOXP3 Tregs involved and their mechanisms in breast cancer prognosis. METHODS:The literature study method is used from primary and secondary libraries. The library search used online-based search instruments such as NCBI-PubMed, Google Scholar, and Elsevier. The data obtained were then arranged according to the framework, data on the relationship between FOXP3 Regulatory T Cells and breast cancer, and writing a journal review was carried out according to the given format. Regulators (Tregs) can inhibit anti-tumor immunity and promote tumor growth. Tregs also play a role in inhibiting cytotoxic T lymphocyte cells by inhibiting the release of granules from CD8+, where CD8+ is important in killing tumor cells. FOXP3 is a Treg-specific biomarker and plays an important role in the development and function of Tregs. RESULTS:Studies on the presence of FOXP3+ Tregs in tumors have shown controversial results. Studies in some tumors reported the presence of FOXP3+, indicating a poor prognosis, whereas studies in other tumors found that FOXP3+ correlated with a good prognosis. CONCLUSION:Regulatory T lymphocytes and TILs in invasive breast carcinoma are still not established. Therefore, further research on the Effect of FOXP3 expression of regulatory T lymphocytes on breast cancer is still important.
Keywords: Treg-regulatory T cells, FOXP3, breast cancer
DOI: 10.3233/BD-239002
Journal: Breast Disease, vol. 42, no. 1, pp. 213-218, 2023
