Desmoid fibroma simulating malignant breast neoplasm: A case report and literature review

Article type: Case Report

Authors: Valente, Maria Stella Vasconcelos Sales^a; | Mota, Fábio Augusto Xerez^a | Ricciardi, Bárbara Bezerra^a | de Carvalho Borges, Bárbara Matos^a | de Lucena Feitosa, Enzo Studart^a | de Aquino, Pedro Lucena^a | Valente, Paulla Vasconcelos^{a; b}

Affiliations: [a] Department of Medicine, University of Fortaleza, Fortaleza, Ceará, Brazil | [b] Department of Oncology, Oncoclinc, Fortaleza, Ceará, Brazil

Correspondence: [*] Corresponding author: Maria Stella Vasconcelos Sales Valente, University of Fortaleza, Department of Medicine, Washington Soares, 1321 - 60811-905 - Edson Queiroz, Fortaleza, Ceará, Brazil. Tel.: +55 85 34773000; E-mail: stellavvalente@gmail.com. ORCID: http://orcid.org/0009-0008-6385-7550

Abstract: INTRODUCTION:Desmoid fibroma (DF) is a disorder characterized by strong clonal proliferation of myofibroblasts and fibroblasts. We describe a case of DF that mimicked a breast tumor, along with a review of the literature on the clinical manifestation, diagnostic process, and course of therapy for this combative disease. CASE REPORT:A 34-year-old female patient with breast lump at the junction of the upper quadrants of the left breast. After the diagnosis of DF, it was decided to perform a sectorectomy of the left breast associated with post-quadrant reconstruction, with immunohistochemistry and findings compatible with DF. DISCUSSION:Clinically manifests as a solid mass that is often painless and occasionally adherent to the chest wall. A treatment strategy should be idealized for each patient. Thus, there is the possibility of performing radical surgery for resection and/or radiotherapy, and surgery may be followed by radiotherapy.

Keywords: Breast, desmoid fibroma, neoplasms

DOI: 10.3233/BD-230028

Journal: Breast Disease, vol. 42, no. 1, pp. 319-323, 2023