Correlation between the expression of Ki67 and histopathological grade, tumor size, disease-free survival, and overall survival among breast cancer patients

Article type: Research Article

Authors: Leksono, Radityo Budi^a | Thabry, Rudy^b | Prihantono, Prihantono^a; | Nahusuly, Fritz^c | Kasim, Firdaus^d | Hamdani, William^e | Pieter, John^e | Indra, Indra^e | Syamsu, Salman Ardi^e | Faruk, Muhammad^a

Affiliations: [a] Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [b] Division of Oncology, Department of Surgery, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia | [c] Department of Surgery, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia | [d] Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia | [e] Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Correspondence: [*] Corresponding author: Prihantono, Department of Surgery, Faculty of Medicine, Hasanuddin University Makassar, Indonesia Jalan Perintis Kemerdekaan KM 11, Makassar, 90245, Indonesia. Fax: +62 41 158 59 84; E-mail: prihantono.md@gmail.com. ORCIDs: https://orcid.org/0000-0002-8247-0457 (P. Prihantono); https://orcid.org/0000-0001-5801-6628 (F. Nahusuly); https://orcid.org/0000-0002-7162-8845 (S.A. Syamsu); https://orcid.org/0000-0002-7079-4585 (M. Faruk)

Abstract: INTRODUCTION:Identifying Ki67, a monoclonal antibody that recognizes proliferating cells, is important for defining the level of proliferative activity among patients with breast cancer. The purpose of our study was to evaluate the correlation between Ki67’s expression and histopathological grade, tumor size, disease-free survival (DFS), and overall survival (OS) among breast cancer patients. METHODS:Our retrospective cohort study involved examining 114 patients with breast cancer at our institution from January 2018 to December 2019. Participants were retrospectively followed to determine the progression of their disease, and their 2-year progress was examined with survival analysis, especially regarding whether they had postoperative relapse (i.e., DFS) or had died since being diagnosed (i.e., OS). The data were processed with a chi-square test and Kaplan–Meier test, with significance set at p < 0.05. RESULT:The overexpression of Ki67 correlated significantly with histopathological grade (p = 0.001), tumor size (p = 0.001), DFS (p = 0.001), and OS (p = 0.003). CONCLUSION:Ki67’s overexpression is significantly correlated with the tumor size, DFS, and OS of patients with breast cancer.

Keywords: Ki67, histopathological grade, tumor size, disease-free survival, overall survival

DOI: 10.3233/BD-229005

Journal: Breast Disease, vol. 41, no. 1, pp. 455-460, 2022