Affiliations: [a] Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [b] Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung, Sengkang, Indonesia | [c] Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University, Makassar, Indonesia
Correspondence:
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Corresponding author: Prihantono Prihantono, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. E-mail: prihantono.md@gmail.com
Abstract: BACKGROUND:With essential metals being studied and developed as anticancer agents, this study aims to explore the anticancer activity of Zn(II) arginine dithiocarbamate in the T47D and fibroblast cell lines. METHOD:The Zn(II) arginine dithiocarbamate complex was prepared by the in situ method and characterized using infra-red spectroscopy, melting point, X-ray fluorescence, and X-ray diffraction instruments. The complex compound was tested for its cytotoxicity to the T47D breast cancer and fibroblast cell lines. RESULTS:The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to the T47D breast cancer cell line obtained IC50 = 3.16 μg/mL, while cisplatin obtained IC50 = 28.18 μg/mL. The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to fibroblast cells obtained IC50 = 8709.63 μg/mL. CONCLUSION:The Zn(II) arginine dithiocarbamate complex has increased active cytotoxicity compared to cisplatin in inducing morphological changes in the T47D breast cancer cell line and is relatively non-toxic to fibroblast cells.
Keywords: Complexes, Zn(II) arginine dithiocarbamate, breast cancer; T47D, cytotoxic
DOI: 10.3233/BD-219008
Journal: Breast Disease, vol. 40, no. s1, pp. S55-S61, 2021
