Fibroadenoma of the breast; incidence of malignancy and indicators for surgical intervention: An analysis of 1392 patients

Article type: Research Article

Authors: Elnahas, Waleed^a | Metwally, Islam H.^a | Bonna, Khaled^a | Youssef, Marco^a | AbdAllah, Samar^a | Bonna, Mohamed^b | Ali Faried, Mohamed^b | Atef Tira, Mohamed^b | Hamdy, Omar^a;

Affiliations: [a] Surgical Oncology Unit, Oncology Center Mansoura University (OCMU), Mansoura, Egypt | [b] Medical Students, Mansoura University Faculty of Medicine, Mansoura, Egypt

Correspondence: [*] Corresponding author: Omar Hamdy, Surgical Oncology Unit, Oncology Center Mansoura University, Mansoura 35516, Egypt. Tel.: +201003526752; E-mail: omarhamdy87@gmail.com. ORCID: https://orcid.org/0000-0002-2924-4207

Abstract: BACKGROUND:Fibroadenomas are common among young females. The size of the lesion used to be an indication for further assessment or excision. With arising of the watch and see proponents, criteria for selecting patients are important to establish. METHODS:This is a retrospective study of a prospectively maintained database where all patients having the clinical/radiological provisional diagnosis of fibroadenoma and attending our center - from January 2008 to March 2020 - were enrolled. The primary outcome was the incidence of malignancy and the secondary outcomes were the correlation of malignancy-risk with epidemiologic and radiologic criteria. RESULTS:The study enrolled 1392 patients. The mean age of the patients was 35.7 + ∕− 13.1 years. The median of the longest diameter of the detected breast lesions was 25 mm. The incidence of malignancy was 188 (13.5%). The size of the lesion measured by largest diameter was insignificant (p = 0.99), while the patients’ age, marital status, and imaging criteria as measured by BIRADS score were significant (<0.001). CONCLUSION:Approaching patients with the age above 35 or with BIRADS 4 provisionally diagnosed with fibroadenomas should be cautious with biopsy and short-term follow-ups The size of the tumor alone should not be used as an indication for surgical intervention.

Keywords: Breast lump, fibroepithelial tumor, breast cancer, phyllodes tumor

DOI: 10.3233/BD-210074

Journal: Breast Disease, vol. 41, no. 1, pp. 421-426, 2022