Affiliations: [a] Sault Area Hospital, Algoma District Cancer Program, Sault Ste. Marie, ON, Canada | [b] Section of Internal Medicine, Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada
Correspondence:
[*]
Corresponding author: Ioannis A. Voutsadakis, M.D., Ph.D., Algoma District Cancer Program, Sault Area Hospital, 750 Great Northern Road, Sault Ste Marie, ON P6B 0A8, Canada. E-mail: ivoutsadakis@yahoo.com, ivoutsadakis@nosm.ca
Abstract: INTRODUCTION:Losses of genetic material from chromosomes 5q and 16q commonly occur in sub-sets of breast cancer. Their significance from a pathophysiologic point of view is not well-defined. METHODS:This study uses publicly available genomic data from extensive breast cancer datasets to define the landscape of losses in chromosomal arms 5q and 16q in the two sub-types of breast cancer they most commonly occur, basal-like and luminal A cancers, respectively. RESULTS:It is shown that dozens of genes from these chromosomal arms are putatively hemi-deleted in few samples each. No individual gene from either 5q or 16q shows an incidence of deep deletion above 10% in the cohorts with basal-like and luminal A cancers or in the whole cohorts. A few tumor suppressor genes are deleted in a small number of samples, less than 5% in each cohort. Losses of 5q or 16q confer no survival advantage in either the basal-like or the luminal A cohorts from TCGA that harbor them. CONCLUSION:Results suggest that there are no individual genes in chromosomes 5q and 16q whose loss can be implicated in a dominant pathophysiologic sequence of events in breast cancer or its sub-sets.
Keywords: Breast cancer, luminal A, basal-like, chromosome arm loss, aneuploidy, TCGA, METABRIC
DOI: 10.3233/BD-210047
Journal: Breast Disease, vol. 41, no. 1, pp. 331-341, 2022
