Affiliations: [a] Cell and Molecular Biology Division, Department of Botany, University of Calicut, Kerala, India
Correspondence:
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Corresponding author: Parakunnel Ravi Ramya Sree, Research scholar, Cell and Molecular Biology Division, Department of Botany, University of Calicut, Kerala 673635, India. Tel.: 9656557736; E-mail: ramyasreeprwynd@gmail.com
Abstract: Breast cancer is one of the leading cancers nowadays. The genetical mechanism behind breast cancer development is an intricate one. In this review, the genetical background of breast cancer, particularly BRCA 1 and BRCA 2 had been included. Moreover, to summarize the genetics of breast cancer, the recent and ongoing preclinical and clinical studies on the treatment of BRCA-associated breast cancer had also been included. A prime knowledge is that the BRCA gene is the basis of breast cancer risk. How it mediates cell proliferation and associated mechanisms are reviewed here. BRCA 1 gene can influence all phases of the cell cycle and regulate cell cycle progression. BRCA 1 gene can also respond to DNA damages and induce responsive mechanisms. The action of the BRCA gene on associated protein has a wide consideration in breast cancer development. Heterogeneity in breast cancer makes them a fascinating and challenging stream to diagnose and treat. Several clinical therapies are available for breast cancer treatments. Chemotherapy, endocrine therapy, radiation therapy and immunotherapy are the milestones in the cancer treatments. Ral binding protein 1 is a promising target for breast cancer treatment and the platinum-based chemotherapies are the other remarkable fields. In immunotherapy, the usage of anti-programmed death (PD)-1 antibody is a new class of cancer immunotherapy that hinders immune effecter inhibition and potentially expanding preexisting anticancer immune responses. Breast cancer genetics and treatment strategies are crucial in escalating survival rates.
Keywords: Breast cancer, BRCA1, cell cycle arrest, BRCA2, DNA damages, therapies
DOI: 10.3233/BD-201040
Journal: Breast Disease, vol. 40, no. 3, pp. 143-154, 2021
