Malignant phyllodes tumor of the breast with liposarcomatous differentiation and intraductal hyperplasia

Article type: Case Report

Authors: Ayadi-Kaddour, Aïda^{a; *} | Zeddini, Abdelfatteh^b | Braham, Emna^a | Ismail, Olfa^a | Mlika, Mona^a | Guelmami, Karim^c | El Mezni, Faouzi^a

Affiliations: [a] Department of Pathology, Abderrahmen Mami Hospital, Ariana, Tunisia | [b] Department of Pathology, Kef Hospital, EI Kef, Tunisia | [c] Department of Gynecology and Obstetrics, Kef Hospital, EI Kef, Tunisia

Correspondence: [*] Corresponding author: Aïda Ayadi-Kaddour, Department of Pathology, Abderrahmen Mami Hospital – 2080 Ariana, Tunisia. Tel.: +216 22 551 641; E-mail: kaddour1fr@yahoo.fr

Abstract: Phyllodes tumor of the breast is a biphasic fibroepithelial neoplasm. 10 to 20% of phyllodes tumor show malignant transformation, often in the form of stroma, which usually shows fibrosarcomatous differentiation and rarely heterologous sarcomatous elements. Liposarcomatous differentiation is not common among phyllodes tumors. The correct diagnosis of heterologous liposarcomatous differentiation in a malignant PT requires identification of the biphasic component of the tumor. We reported a case of malignant phyllodes tumor which initially transformed into liposarcoma, in addition to a very rare intraductal hyperplasia and flat epithelial atypia. The patient was a 75-year-old woman, with a lump in the left breast without axillary lymphadenopathy. She also have a positive family history of breast carcinoma. She underwent surgery and still alive and disease free after one year.

Keywords: Breast, phyllodes tumor, liposarcoma, intraductal hyperplasia

DOI: 10.3233/BD-140377

Journal: Breast Disease, vol. 35, no. 1, pp. 59-62, 2015