Affiliations: [a] Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA | [b] Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA | [x] Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA | [y] Clinical Trial Evaluation Program (CTEP), National Cancer Institute, Bethesda MD, USA
Correspondence:
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Corresponding author: Jason Herschkowitz, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, DeBakey M635, Houston, TX 77030, USA. Lab: +1 713 798 6211; Cell: +1 713 935 6706; E-mail: herschko@bcm.edu
Abstract: Triple negative breast cancer encompasses the molecular subtypes of basal-like and the more recently defined claudin-low group. In this review, we discuss the identification and characterization of mouse models that mimic these human subtypes. These mouse models serve as useful tools for the study of disease biology and represent a valuable resource for the evaluation of experimental therapeutics.
DOI: 10.3233/BD-2010-0321
Journal: Breast Disease, vol. 32, no. 1-2, pp. 63-71, 2011
