Wound Complications from Surgery in Pregnancy-Associated Breast Cancer (PABC)1

Article type: Research Article

Authors: Dominici, Laura S.^a | Kuerer, Henry M.^b | Babiera, Gildy^b | Hahn, Karin M.E.^c | Perkins, George^d | Middleton, Lavinia^e | Ramirez, Mildred M.^f | Yang, Wei^g | Hortobagyi, Gabriel N.^c | Theriault, Richard L.^c | Litton, Jennifer K.^{c; *}

Affiliations: [a] Department of Surgical Oncology, Brigham and Women's Hospital, Boston, MA, USA | [b] Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA | [c] Department of Breast Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA | [d] Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA | [e] Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA | [f] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School at Houston, Houston, TX, USA | [g] Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

Correspondence: [*] Corresponding author: Jennifer K Litton, MD, Department of Breast Medical Oncology, Unit 1354, University of Texas M.D. Anderson Cancer Center, P.O. Box 301439, Houston, TX, USA. Tel.: +1 77230 1439; +1 713 792 2817; Fax: +1 713 7944385; E-mail: jlitton@mdanderson.org

Abstract: Background:There are concerns that physiologic changes of the peripartum breast may result in complications in breast conservation therapy. We present the complications of breast conservation surgeries and mastectomies performed for pregnancy-associated breast cancer (PABC). Materials and methods:From April 1989 through April 2008, sixty-seven breast cancer patients underwent surgical management for PABC, defined as surgery during pregnancy or within one year postpartum. Records of women who had surgery were examined for post-operative wound complications of milk fistula, cellulitis, abscess, or hematoma. Results:Forty-seven patients underwent mastectomy. Twenty were treated with conservative breast surgery. There were six complications, all treated in the outpatient setting. There were no documented milk fistulae. Conclusions:In our series, we had few postoperative complications and no milk fistulae for those patients undergoing surgery for PABC. When compared to those who had mastectomy for PABC, women who underwent breast conserving therapy did not appear to have increased frequency of surgical complications.

Keywords: Breast cancer, pregnancy, conservative surgery, treatment, complications

DOI: 10.3233/BD-2009-0289

Journal: Breast Disease, vol. 31, no. 1, pp. 1-5, 2010