Progestins and Breast Cancer

Issue title: Hormones and Breast Cancer in Postmenopausal Women

Guest editors: Sandra Z. Haslam and Janet R. Osuch

Article type: Research Article

Authors: Aupperlee, Mark^{a; c} | Kariagina, Anastasia^{a; c} | Osuch, Janet^{b; c} | Haslam, Sandra Z.^{a; c; *}

Affiliations: [a] Department of Physiology, Michigan State University. East Lansing, MI, USA | [b] Departments of Epidemiology, and Surgery, Michigan State University. East Lansing, MI, USA | [c] Breast Cancer and the Environment Research Center, Michigan State University, East Lansing, MI, USA | Michigan State University, East Lansing, MI, USA

Correspondence: [*] Corresponding author: Sandra Z. Haslam, Ph.D., Department of Physiology, 2201 Biomedical & Physical Sciences Bldg., Michigan State University, East Lansing, MI 48824, USA. Tel.: +1 517 355 6475 ext. 1154; Fax: +1 517 355 5125; E-mail: shaslam@msu.edu

Abstract: Progesterone (P) regulates proliferation and differentiation in the normal mammary gland in mouse, rat and human. Progesterone has also been implicated in the etiology and pathogenesis of human breast cancer. The focus of this review is on recent advances in understanding the role of the progesterone receptor (PR) and functional significance of PR isoforms, PRA and PRB, in the normal mammary gland and in mammary cancer in mouse, rat and human.

DOI: 10.3233/BD-2006-24104

Journal: Breast Disease, vol. 24, no. 1, pp. 37-57, 2006