Affiliations: School of Medicine, Tohoku University, Sendai, Japan | Department of Mechanical Engineering, Chiba University, Chiba, Japan | Graduate School of Science and Engineering, Saitama University, Saitama, Japan | Department of Mechanical Science and Bioengineering, Osaka University, Osaka, Japan | Department of Bioengineering and Robotics, Tohoku University, Sendai, Japan | Department of Biomedical Engineering, Tohoku University, Sendai, Japan
Note: [] Address for correspondence: Dr. Hiroki Kamada, Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan. Tel.: + 81 22 795 6958; Fax: +81 22 795 6959; E-mail: hiroki@pfsl.mech.tohoku.ac.jp.
Abstract: The purpose of this study was to evaluate the effects of stenosis geometry on primary thrombogenesis with respect to the dynamics of the blood flow. A two-dimensional computer simulation was carried out to simulate the formation of a primary thrombus under blood flow in two geometrically different blood vessels: one straight and the other stenosed. In the simulation, blood was modeled by particles that have characteristics of plasma and of platelets. Plasma and platelet flow was analyzed using the Moving Particle Semi-implicit (MPS) method, while the motion of adhered and aggregated platelets was expressed by mechanical spring forces. With these models, platelet motion in the flowing blood and platelet aggregation and adhesion were successfully coupled with viscous blood flow. The results of the simulation demonstrated that the presence of a stenosis induced changes in blood flow and thereby altered the formation, growth, and destruction of a thrombus. In particular, whereas in the absence of stenosis, the thrombus evenly covered the injured site, in the presence of a stenosis, thrombus formation was skewed to the downstream side. The number of platelets that adhered to the injured site increased earlier as the stenosis became more severe. These results suggest that dynamic changes in blood flow due to the presence of a stenosis affect primary thrombogenesis.
