Intravital-microscopic observations on the intravascular behavior of blood cell components during dietary-induced hyperlipidemia in the male rabbit

Issue title: 25th Anniversary Volume. Perspectives in Biorheology II. Festschrift for Syoten Oka

Guest editors: Eiichi Fukada and Takehiko Azuma

Article type: Research Article

Authors: Asano, M. | Ohkubo, C. | Hirokawa, A. | Sasaki, A. | Tochihara, Y. | Chiba, Y.

Affiliations: Department of Physiological Hygiene, the Institute of Public Health, Minato-ku, Tokyo, 108, Japan

Abstract: In normal male rabbits loaded dietary cholesterol, intravital-microscopy revealed a marked acceleration of intravascular adhesiveness of white blood cells and aggregability of red blood cells and a swarming of lipid-laden macrophages in connective tissue space concurrently with a systemic hyperlipidemia and anemia. Possible roles of the microcirculatory changes in the atherogenesis were discussed.

Keywords: atherogenesis, cholesterol feeding, CO inhalation, intravital-microscopy, rabbit ear chamber

DOI: 10.3233/BIR-1988-251-242

Journal: Biorheology, vol. 25, no. 1-2, pp. 329-338, 1988