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Issue title: Workshop: Breaking Symmetry in Haemodynamics, London, UK, 23–24 April 2001
Article type: Research Article
Authors: Butty, V.D. | Gudjonsson, K. | Buchel, P. | Makhijani, V.B. | Ventikos, Y.; | Poulikakos, D.
Affiliations: Laboratory for Thermodynamics in Emerging Technologies, Institute of Energy Technology, Swiss Federal Institute of Technology, Zurich, Switzerland | Biomedical Technology Branch, CFD Research Corporation, Huntsville, AL, USA
Note: [] Address for correspondence: Yiannis Ventikos, LTNT, ETH‐Zentrum, Sonneggstrasse 3, CH‐8092 Zurich, Switzerland. Tel.: + 41 1 632 0785; Fax: + 41 1 632 1176; E‐mail: Yiannis.Ventikos@ethz.ch.
Abstract: We are presenting computational fluid dynamics simulation results for the flow in an anatomically accurate right internal carotid artery, exhibiting two saccular aneurysms close to each other. Our study focuses on the investigation of passage times for blood cells through the two‐aneurysm malformation. We construct residence time maps that exhibit strong non‐uniformity, linked to the entry of fluid in only the first, only the second, or in both aneurysms. An entrance index is computed, showing qualitatively the regions at an arterial section upstream of the aneurysms, where cells following one of these scenarios emanate. The significance of the residence time profiles and entry scenarios obtained is discussed with respect to thrombosis and pharmacokinetics. Preliminary evidence that the inflow–outflow patterns of the two aneurysms may be leading to particularly complex flow and to chaotic mixing is discussed.
Keywords: CFD, cerebral aneurysm, residence times, basins of attraction, chaotic advection
Journal: Biorheology, vol. 39, no. 3-4, pp. 387-393, 2002
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