An energy density function for the heart encompassing both elastic and contractile properties¹

Article type: Research Article

Authors: Klip, Willem^a | Janicki, Joseph S.^{b; *} | Klip, Dorothea A.^c | Reeves, Russell C.^d

Affiliations: [a] Departments of Physiology and Biophysics, Medicine and Physics, University of Alabama in Birmingham, Birmingham, Alabama 35294 | [b] Department of Medicine, University of Alabama in Birmingham | [c] Departments of Physiology and Biophysics and Information Sciences, University of Alabama in Birmingham, Alabama 35294 | [d] Department of Medicine, University of Alabama in Birmingham, Birmingham, Alabama 35294

Note: [1] This work was supported by PHS Program Project Grant No. HEl1310.

Note: [*] Present address: Cardiovascular Pulmonary Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Note: [] Accepted by: Editor E. Fukada

Abstract: The calculations leading to an energy density function for heart muscle encompassing both elastic and contractile properties are explicitly given. The function has two variables Q (measuring deformation) and Qc (measuring contraction). The time dependence of the contraction variable (Qc) was found to be largely independent of preload and afterload. This increases the possibility of its clinical determination and that of the constants in the energy density function for diagnostic and prognostic purposes.

DOI: 10.3233/BIR-1978-153-415

Journal: Biorheology, vol. 15, no. 3-4, pp. 277-293, 1978