Some hemorheological and hematological parameters in heterozygous β-thalassemia¹

Article type: Research Article

Authors: Stasiw, D.M.^a | Puccini, C.^a | Cerny, L.C.^{a; *} | Ziegler, F.^b | Grimley, P.^b

Affiliations: [a] Masonic Medical Research Laboratory and Utica College, Utica, N.Y. | [b] New York State Department of Health, Div. Laboratories and Research, Albany, N.Y.

Correspondence: [*] To whom all correspondence should be sent.

Note: [1] This work was supported in part by a grant from the National Foundation-March of Dimes, No. 1–319.

Abstract: The results of a screening program for heterozygous thalassemia involving 1039 subjects are reported. Identification of possible thalassemia carriers was made on the basis of standard blood indices and quantitative hemoglobin A2 measurements. Various mathematical relationships reported as discriminant functions for possible thalassemia carriers were tested using these data. None of the currently proposed methods suitable for use in a mass screening program performed successfully. Besides the normal hematological parameters, hemorheological variables including shear viscometry, erythrocyte sedimentation rate and osmotic fragility were also studied.

DOI: 10.3233/BIR-1977-14101

Journal: Biorheology, vol. 14, no. 1, pp. 1-10, 1977