Applications of a theoretical model for haemolysis in shear flow

Article type: Research Article

Authors: Richardson, Elspeth

Affiliations: Department of Applied Mathematics and Theoretical Physics, Silver Street, Cambridge CB3 9EW

Abstract: A theoretical model for haemolysis in a uniform shear flow has been developed previously. The possibility of applying this model, and simple extensions of it, to in vitro high shear-rate experiments is explored. Criteria for adequate uniformity of the flow field are developed. For rotating viscometers the dependence of haemolysis time on shear rate is predicted; for capillary tubes the dependence of percentage haemolysis on flow rate and tube dimensions. The flows in the jet test and oscillating wire experiment are shown to be insufficiently uniform for this method of analysis, and the consequences of this are investigated.

DOI: 10.3233/BIR-1975-12105

Journal: Biorheology, vol. 12, no. 1, pp. 27-37, 1975