A model for the sickle cell. I—hemorheology and II—microcalorimetry

Article type: Research Article

Authors: Cerny, L.C. | Cook, F.B. | Stasiw, D.M.

Affiliations: Masonic Medical Research Laboratory and Utica College, Utica, New York 13501

Abstract: The viscosity of whole blood was determined on subjects with sickle cell trait. This study was performed on an aging population with a Wells Brookfield cone-plate viscometer. The investigation indicated an age-related pattern. The viscosity-shear rate curve of whole blood of the young SA age group is at least 23 per cent greater than the young AA age group. One old SA patient showed a hemorheological flow pattern similar to the data of oxygenated SS blood. Initial measurements employing a microcalorimcter indicate the usefulness of this technique. It appears possible to distinguish a difference in the heat of mixing urea with HbAA and HbAS. These experiments also point to the use of microcalorimetry for objective evaluation of sickle cell therapy, and for prediction of therapeutic drug dosages.

DOI: 10.3233/BIR-1974-11403

Journal: Biorheology, vol. 11, no. 4, pp. 235-239, 1974