The top 100 cited cholesterol papers
Abstract
We have compiled a list of the 100 most cited articles in cholesterol research to assess research trends over the last 10 and 100 years to mark the 200th anniversary of the naming of cholesterol as part of the special issue of Biomedical Spectroscopy and Imaging.
1.Introduction
2016 is the 200th anniversary of the naming of cholesterol [1] and as part of the special issue of Biomedical Spectroscopy and Imaging to mark this milestone, this article presents an analysis of the most cited articles on cholesterol in an attempt to identify the most widely read and influential articles on the subject and give the authors the recognition they deserve. Such an analysis of cited papers can also identify trends, provide guidance for future research and highlight where there are insufficiencies in the current literature [1,2].
2.Methods and limitations
As with many areas of biomedicine, the field of cholesterol research historically has had a strong divide between biochemical and physiological investigations. As we began the process of selecting the 100-most-cited papers in the field this divide was in clear evidence. Most of the papers fell into one of the following categories:
(1) Methods for measuring cholesterol
(2) Cholesterol metabolism/homeostasis
(3) Cholesterol and disease
(4) Cholesterol lowering drugs
(5) Cholesterol biochemistry/biophysics
While the major interest of the journal is in the fifth category we felt it would also be interesting to look at the wider picture to mark this anniversary. Citation data are not readily available for papers published more than 100 years ago and for this reason we focused on the last 100 years and also, for comparison the last 10 years.
It is important to recognize that any search strategy represents an approximation to the field.
The data used in the tabulation of each originate from the Web of Science Core Collection database which includes but is not limited to all papers indexed by the NIH’s Medline database. Two selection filters were used to determine which papers would contribute to an article’s metrics. The first requirement was that all papers to be included in the analysis contained the search term “cholesterol” in the title field. Reviews were included in the analysis because, while it is relatively “easy” to write a review, it is very difficult to write a review that is well cited. Well-cited reviews tend to be authored by leaders in the field and present conceptual advances or new hypotheses that can be as important as experimental advances.
The second filter is temporal: only papers published and subsequently indexed in Web of Science Core Collection between January 1, 1916 and December 31, 2015 were considered for the 100 year analysis and only papers published and subsequently indexed in Web of Science Core Collection between January 1, 2006 and December 31, 2015 were considered for the 10 year analysis. The queries for the two document sets were conducted on February 2, 2016 and March 29, 2016 respectively.
It is important to recognize that citation scores are, by necessity, close approximations rather than absolute values, the latter not being possible because all citation tools have slightly different variables (e.g. journals indexed, time period covered, data reliability).
3.Results
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
1 | 1972 | Friedewa, WT; Fredrick, DS; Levy, RI | Estimation of concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge | CLINICAL CHEMISTRY | 16,697 |
2 | 2001 | Cleeman, JI; Grundy, SM; Becker, D; Clark, LT; Cooper, RS; Denke, MA; Howard, WJ; Hunninghake, DB; Illingworth, DR; Luepker, RV; McBride, P; McKenney, JM; Pasternak, RC; Stone, NJ; Van Horn, L; Brewer, HB; Ernst, ND; Gordon, D; Levy, D; Rifkind, B; Rossouw, JE; Savage, P; Haffner, SM; Orloff, DG; Proschan, MA; Schwartz, JS; Sempos, CT; Shero, ST; Murray, EZ | Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 12,564 |
3 | 1994 | Pedersen, TR; Kjekshus, J; Berg, K; Haghfelt, T; Faergeman, O; Thorgeirsson, G; Pyorala, K; Miettinen, T; Wilhelmsen, L; Olsson, AG; Wedel, H; Kristianson, K; Thomsen, H; Nordero, E; Thomsen, B; Lyngborg, K; Andersen, GS; Nielsen, F; Talleruphuus, U; Mcnair, A; Egstrup, K; Simonsen, EH; Simonsen, I; Vejbychristensen, H; Sommer, L; Eidner, PO; Klarholt, E; Henriksen, A; | Randomized trial of cholesterol-lowering in 4444 patients with coronary-heart-disease – The Scandinavian Simvastatin Survival Study (4S) | LANCET | 7573 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
Mellemgaard, K; Launbjerg, J; Freuergaard, P; Nielsen, L; Madsen, EB; Ibsen, H; Andersen, U; Enemark, H; Haarbo, J; Martinsen, B; Dahlstrom, CG; Thyrring, L; Thomassen, K; Jensen, G; Rasmussen, SL; Skov, N; Hansen, KN; Larsen, ML; Haastrup, B; Hjaere, I; Thuroe, A; Leth, A; Munch, M; Worck, R; Nielsen, B; Thorn, AG; Pedersenbjergaard, O; Fournaise, B; Sigurd, B; Enk, B; Nielsen, H; Jacobsen, L; Svendsen, TL; Hoegholm, A; Munter, H; Kaufmann, P; Haunso, S; Grande, P; Eriksen, C; Nielsen, HH; Jurlander, B; Pinborg, T; Pindborg, J; Tost, H; Christiansen, BD; Oppenhagen, M; Egede, F; Hvidt, S; Kjaerby, T; Lemming, L; Klausen, I; Miettinen, TA; Vanhanen, H; Strandberg, TE; Holtta, K; Luomanmaki, H; Pekuri, T; Vuorinen, A; Pasternack, A; Oksa, H; Siitonen, L; Rimpi, R; Kesaniemi, YA; Lilja, M; Korhonen, T; Rantala, A; Rantala, M; Savolainen, M; Ukkola, O; Laine, L; Virkkala, L; Lehto, S; Miettinen, H; Salokannel, A; Raisanen, R; Hognason, J; Kristjansdottir, H; Thorvaldsdottir, G; Sigurdsson, G; Sverrisson, JT; Hansteen, V; Kjelsberg, F; Berget, K; Pettersen, R; Balto, ER; Holm, T; Gundersen, T; Aslaksen, B; Andersen, EH; Torsvik, H; Faber, A; Indrebo, T; Ose, A; Roterud, T; Holstlarsen, L; Waage, K; Holstlarsen, E; Haerem, JW; Aukrust, P; Torp, R; Risberg, K; Mauseth, K; Gerdts, E; Nygard, O; Hallaraker, A; Gradek, G; Vangen, EM; Schartumhansen, H; Refsum, AM; Listerud, S; Gundersrud, B; Stene, AM; Klykken, B; Aakervik, O; Loraas, A; Foss, PO; Haga, A; Thoresen, L; Drivenes, A; Lem, P; Gabrielsen, F; Hestad, S; Rode, R; Haug, BK; Skjelvan, G; Eldorsen, E; Ytrearne, K; Rasmussen, K; Myhre, ESP; Nermoen, I; Christiansen, L; Karlsen, AS; Walberg, K; Tjonndal, HA; Kulseng, B; Rokseth, R; Nergard, TV; Roe, MO; Tenstad, O; Lofsnes, IL; Bergsrud, U; Melberg, TH; Vonbrandis, C; Barvik, S; Woie, L; |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
Abrahamsen, AM; Aarsland, T; Svanes, H; Noer, G; Nordlie, KE; Hanedalen, AE; Johansen, T; Larsen, CB; Ostholm, E; Overskeid, K; Sandvei, P; Johansen, A; Sognen, E; Aarskog, D; Dale, A; Hegrestad, S; Reikvam, A; Hawkes, L; Hoff, S; Torjussen, T; Norvik, R; Jorgensen, C; Hjermann, I; Leren, P; Narvestad, A; Fausa, D; Gjestvang, FT; Nordland, B; Brunmark, P; Bioklund, H; Bioklund, B; Forsberg, H; Bergstrom, B; Laaksonen, I; Vestermark, MB; Mascher, G; Hammarstrom, E; Trosell, K; Karlsson, L; Hallstrom, L; Stjerna, A; Slette, MK; Diderholm, E; Pberglund, K; Linde, B; Ahlmark, G; Saetre, H; Ahlberg, G; Sundkvist, K; Gustafsson, PE; Gustafsson, E; Norrby, A; Jaup, B; Svensson, L; Wiklund, O; Linden, T; Bergh, CH; Jonsteg, K; Bonnier, B; Lundin, Y; Romanus, K; Ulvenstam, G; Johansson, S; Wallin, I; Dudas, K; Andreasson, M; Torelund, G; Skarfors, E; Ruter, G; Akesson, L; Wagner, F; Ljungdahl, L; Wagner, V; Rasmanis, G; Edhag, O; Vourisalo, D; Hjelmsell, H; Wesley, G; Lundkvist, L; Angman, K; Olsson, A; Svenson, O; Kuylenstierna, J; Frisenettefich, K; Bergman, E; Stromblad, H; Jensen, S; Jonsson, E; Levin, C; Odeberg, H; Bengtsson, PO; Holmesson, E; Hedstrand, H; Bojo, L; Oberg, S; Leksell, H; Werner, P; Persson, S; Simonsson, M; Wirenstam, UB; Moberg, B; Ekstrand, AB; Nicol, P; Malmros, B; Saaw, J; Arcini, N; Kobosko, J; Anevik, IG; Gyland, F; Lundh, B; Wennerholm, M; Olsson, C; Kjellberg, J; Fabianson, K; Fraser, T; Bergkvist, I; Bergdahl, B; Fluur, C; Wajerstam, S; Svensson, KA; Ekholm, L; Torebo, E; Ryberg, A; Frisell, JE; Hedman, A; Wallrup, L; Andersen, G; Sandstrom, M; Alberg, K; Fagher, B; Thulin, T; Svenstam, I; Bjurman, A; Skoglund, E; Dahl, G; Kjellstrom, T; Juhlin, P; Sjooboquist, M; Sjogren, A; Loogna, E; Jansson, T; Friden, J; |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
Nilsson, O; Andersson, PO; Henriksson, C; Ellstrom, J; Brodersson, H; Lundquist, L; Aslund, M; Boman, K; Jansson, JH; Norrfors, B; Hoglund, C; Lundblad, M; Liljefors, I; Wennerstrom, L; Perz, I; Leijd, B; Falkenberg, C; Bergsten, L; Strom, S; Engstrom, AC; Ejdeback, J; Malmberg, K; Hogstrom, S; Stahl, L; Moller, BH; Lycksell, M; Soderstrom, M; Hansson, E; Hallen, C; Stakebarg, H; Borretzen, J; Heden, B; Andersson, K; Johnson, O; Birgander, LS; Elander, B; Lidell, C; Andersson, PE; Marklund, E; Dahlen, M; Rucker, F; Lofqvist, M; Wannberg, B; Lim, BH; Larsson, O; Andersson, G; Hansson, A; Uchto, M; Gowenius, M; Uggeldahl, I; Ursing, D; Hammarlund, P; Nyman, P; Tsuppuka, E; Malmberg, L; Goransson, K; Hasselgren, P; Insberg, CM; Petterson, S; Ahrlin, A; Lovheim, O; Andersson, LO; Grundstrom, I | |||||
4 | 1974 | Allain, CC; Poon, LS; Chan, CSG; Richmond, W; Fu, PC | Enzymatic determination of total serum-cholesterol | CLINICAL CHEMISTRY | 5978 |
5 | 1989 | Steinberg, D; Parthasarathy, S; Carew, TE; Khoo, JC; Witztum, JL | Beyond cholesterol – Modifications of low-density lipoprotein that increase its atherogenicity | NEW ENGLAND JOURNAL OF MEDICINE | 5920 |
6 | 1996 | Sacks, FM; Pfeffer, MA; Moye, LA; Rouleau, JL; Rutherford, JD; Cole, TG; Brown, L; Warnica, JW; Arnold, JMO; Wun, CC; Davis, BR; Braunwald, E | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels | NEW ENGLAND JOURNAL OF MEDICINE | 4789 |
7 | 2002 | Collins, R; Armitage, J; Parish, S; Sleight, P; Peto, R | MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial | LANCET | 4533 |
8 | 1986 | Brown, MS; Goldstein, JL | A receptor-mediated pathway for cholesterol homeostasis | SCIENCE | 3940 |
9 | 1952 | Abell, LL; Levy, BB; Brodie, BB; Kendall, FE | A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity | JOURNAL OF BIOLOGICAL CHEMISTRY | 3630 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
10 | 1998 | Tonkin, A; Aylward, P; Colquhoun, D; Glasziou, P; Harris, P; MacMahon, S; Magnus, P; Newel, D; Nestel, P; Sharpe, N; Hunt, D; Shaw, J; Simes, RJ; Thompson, P; Thomson, A; West, M; White, H; Simes, S; Hague, W; Caleo, S; Hall, J; Martin, A; Mulray, S; Barter, P; Beilin, L; Collins, R; McNeil, J; Meier, P; Willimott, H; Smithers, D; Wallace, P; Sullivan, D; Keech, A | Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels | NEW ENGLAND JOURNAL OF MEDICINE | 3586 |
11 | 1998 | Downs, JR; Clearfield, M; Weis, S; Whitney, E; Shapiro, DR; Beere, PA; Langendorfer, A; Stein, EA; Kruyer, W; Gotto, AM | Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels – Results of AFCAPS/TexCAPS | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 3383 |
12 | 2004 | Grundy, SM; Cleeman, JI; Merz, CNB; Brewer, HB; Clark, LT; Hunninghake, DB; Pasternak, RC; Smith, SC; Stone, NJ | Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines | CIRCULATION | 3212 |
13 | 2005 | Baigent, C; Keech, A; Kearney, PM; Blackwell, L; Buck, G; Pollicino, C; Kirby, A; Sourjina, T; Peto, R; Collins, R; Simes, J | Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins | LANCET | 3000 |
14 | 1988 | Mahley, RW | Apolipoprotein-E – Cholesterol transport protein with expanding role in cell biology | SCIENCE | 2977 |
15 | 1953 | Zlatkis, A; Zak, B; Boyle, AJ | A new method for the direct determination of serum cholesterol | JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 2590 |
16 | 1950 | Sperry, WM; Webb, M | A revision of the schoenheimer-sperry method for cholesterol determination | JOURNAL OF BIOLOGICAL CHEMISTRY | 2516 |
17 | 1968 | Glomset, JA | Plasma lecithin – Cholesterol acyltransferase reaction | JOURNAL OF LIPID RESEARCH | 2227 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
18 | 1979 | Goldstein, JL; Ho, YK; Basu, SK; Brown, MS | Binding-site on macrophages that mediates uptake and degradation of acetylated low-density lipoprotein, producing massive cholesterol deposition | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2110 |
19 | 2002 | Ridker, PM; Rifai, N; Rose, L; Buring, JE; Cook, NR | Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events | NEW ENGLAND JOURNAL OF MEDICINE | 2060 |
20 | 1999 | Rubins, HB; Robins, SJ; Collins, D; Fye, CL; Anderson, JW; Elam, MB; Faas, FH; Linares, E; Schaefer, EJ; Schectman, G; Wilt, TJ; Wittes, J | Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol | NEW ENGLAND JOURNAL OF MEDICINE | 2055 |
21 | 1983 | Brown, MS; Goldstein, JL | Lipoprotein metabolism in the macrophage – Implications for cholesterol deposition in atherosclerosis | ANNUAL REVIEW OF BIOCHEMISTRY | 2018 |
22 | 2003 | Sever, PS; Dahlof, B; Poulter, NR; Wedel, H; Beevers, G; Caulfield, M; Collins, R; Kjeldsen, SE; Kristinsson, A; McInnes, GT; Mehlsen, J; Nieminen, M; O’Brien, E; Ostergren, J | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial | LANCET | 2003 |
23 | 1997 | Brown, MS; Goldstein, JL | The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor | CELL | 1990 |
24 | 2002 | Horton, JD; Goldstein, JL; Brown, MS | SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver | JOURNAL OF CLINICAL INVESTIGATION | 1903 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
25 | 1989 | Gordon, DJ; Probstfield, JL; Garrison, RJ; Neaton, JD; Castelli, WP; Knoke, JD; Jacobs, DR; Bangdiwala, S; Tyroler, HA | High-density lipoprotein cholesterol and cardiovascular-disease – 4 prospective American-studies | CIRCULATION | 1888 |
26 | 1971 | Kannel, WB; Castelli, WP; Gordon, T; Mcnamara, PM | Serum cholesterol, lipoproteins, and risk of coronary heart disease – Framingham study | ANNALS OF INTERNAL MEDICINE | 1884 |
27 | 1993 | Grundy, SM; Bilheimer, D; Chait, A; Clark, LT; Denke, M; Havel, RJ; Hazzard, WR; Hulley, SB; Hunninghake, DB; Kreisberg, RA; Krisetherton, P; Mckenney, JM; Newman, MA; Schaefer, EJ; Sobel, BE; Somelofski, C; Weinstein, MC; Brewer, HB; Cleeman, JI; Donato, KA; Ernst, N; Hoeg, JM; Rifkind, BM; Rossouw, J; Sempos, CT; Gallivan, JM; Harris, MN; Quintadler, L | Summary of the 2nd report of the national-cholesterol-education-program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult-treatment-panel-II) | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1809 |
28 | 1982 | Warnick, GR; Benderson, J; Albers, JJ | Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol | CLINICAL CHEMISTRY | 1738 |
29 | 1986 | Castelli, WP; Garrison, RJ; Wilson, PWF; Abbott, RD; Kalousdian, S; Kannel, WB | Incidence of coronary heart-disease and lipoprotein cholesterol levels – The Framingham-study | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1715 |
30 | 2000 | Brown, DA; London, E | Structure and function of sphingolipid- and cholesterol-rich membrane rafts | JOURNAL OF BIOLOGICAL CHEMISTRY | 1638 |
31 | 2003 | Collins, R; Armitage, J; Parish, S; Sleight, P; Peto, R | MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial | LANCET | 1584 |
32 | 1977 | Castelli, WP; Doyle, JT; Gordon, T; Hames, CG; Hjortland, MC; Hulley, SB; Kagan, A; Zukel, WJ | HDL cholesterol and other lipids in coronary heart-disease – Cooperative lipoprotein phenotyping study | CIRCULATION | 1513 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
33 | 1986 | Stamler, J; Wentworth, D; Neaton, JD | Is relationship between serum-cholesterol and risk of premature death from coronary heart-disease continuous and graded – Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT) | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1448 |
34 | 1980 | Alberts, AW; Chen, J; Kuron, G; Hunt, V; Huff, J; Hoffman, C; Rothrock, J; Lopez, M; Joshua, H; Harris, E; Patchett, A; Monaghan, R; Currie, S; Stapley, E; Albersschonberg, G; Hensens, O; Hirshfield, J; Hoogsteen, K; Liesch, J; Springer, J | Mevinolin – A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme-A reductase and a cholesterol-lowering agent | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1337 |
35 | 1977 | Lopesvirella, MF; Stone, P; Ellis, S; Colwell, JA | Cholesterol determination in high-density lipoproteins separated by 3 different methods | CLINICAL CHEMISTRY | 1292 |
36 | 1965 | Hegsted, DM; Mcgandy, RB; Myers, ML; Stare, FJ | Quantitative effects of dietary fat on serum cholesterol in man | AMERICAN JOURNAL OF CLINICAL NUTRITION | 1245 |
37 | 1997 | Delmas, PD; Bjarnason, NH; Mitlak, BH; Ravoux, AC; Shah, AS; Huster, WJ; Draper, M; Christiansen, C | Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women | NEW ENGLAND JOURNAL OF MEDICINE | 1201 |
38 | 1978 | Warnick, GR; Albers, JJ | Comprehensive evaluation of heparin-manganese precipitation procedure for estimating high-density lipoprotein cholesterol | JOURNAL OF LIPID RESEARCH | 1191 |
39 | 2010 | Baigent, C; Blackwell, L; Emberson, J; Holland, LE; Reith, C; Bhala, N; Peto, R; Barnes, EH; Keech, A; Simes, J; Collins, R | Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials | LANCET | 1180 |
40 | 1979 | Kannel, WB; Castelli, WP; Gordon, T | Cholesterol in the prediction of atherosclerotic disease – New perspectives based on the framingham study | ANNALS OF INTERNAL MEDICINE | 1161 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
41 | 1995 | Fielding, CJ; Fielding, PE | Molecular physiology of reverse cholesterol transport | JOURNAL OF LIPID RESEARCH | 1159 |
42 | 1968 | Admirand, WH; Small, DM | Physicochemical basis of cholesterol gallstone formation in man | JOURNAL OF CLINICAL INVESTIGATION | 1114 |
43 | 1997 | Pyorala, K; Pedersen, TR; Kjekshus, J; Faergeman, O; Olsson, AG; Thorgeirsson, G | Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease – A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S) | DIABETES CARE | 1113 |
44 | 1985 | Yeagle, PL | Cholesterol and the cell-membrane | BIOCHIMICA ET BIOPHYSICA ACTA | 1079 |
45 | 1976 | Basu, SK; Goldstein, JL; Anderson, RGW; Brown, MS | Degradation of cationized low-density lipoprotein and regulation of cholesterol-metabolism in homozygous familial hypercholesterolemia fibroblasts | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1071 |
46 | 1934 | Schoenheimer, R; Sperry, WM | A micromethod for the determination of free and combined cholesterol | JOURNAL OF BIOLOGICAL CHEMISTRY | 1068 |
47 | 1995 | Treasure, CB; Klein, JL; Weintraub, WS; Talley, JD; Stillabower, ME; Kosinski, AS; Zhang, J; Boccuzzi, SJ; Cedarholm, JC; Alexander, RW | Beneficial-effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary-artery disease | NEW ENGLAND JOURNAL OF MEDICINE | 1010 |
48 | 1959 | Friedman, M; Rosenman, RH | Association of specific overt behavior pattern with blood and cardiovascular findings – Blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1008 |
49 | 1974 | Roschlau, P; Bernt, E; Gruber, W | Enzymatic determination of total cholesterol in serum | ZEITSCHRIFT FUR KLINISCHE CHEMIE UND KLINISCHE BIOCHEMIE | 985 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
50 | 1973 | Richmond, W | Preparation and properties of a cholesterol oxidase from nocardia sp. and its application to enzymatic assay of total cholesterol in serum | CLINICAL CHEMISTRY | 946 |
51 | 2003 | Mensink, RP; Zock, PL; Kester, ADM; Katan, MB | Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials | AMERICAN JOURNAL OF CLINICAL NUTRITION | 937 |
51 | 2000 | Berge, KE; Tian, H; Graf, GA; Yu, LQ; Grishin, NV; Schultz, J; Kwiterovich, P; Shan, B; Barnes, R; Hobbs, HH | Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters | SCIENCE | 937 |
53 | 1992 | Manninen, V; Tenkanen, L; Koskinen, P; Huttunen, JK; Manttari, M; Heinonen, OP; Frick, MH | Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart-disease risk in the Helsinki heart-study – Implications for treatment | CIRCULATION | 925 |
54 | 1986 | Martin, MJ; Browner, WS; Wentworth, D; Hulley, SB; Kuller, LH | Serum-cholesterol, blood-pressure, and mortality – Implications from a cohort of 361,662 men | LANCET | 919 |
55 | 1998 | Peet, DJ; Turley, SD; Ma, WZ; Janowski, BA; Lobaccaro, JMA; Hammer, RE; Mangelsdorf, DJ | Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha | CELL | 918 |
56 | 1973 | Rudel, LL; Morris, MD | Determination of cholesterol using ortho-phthalaldehyde | JOURNAL OF LIPID RESEARCH | 917 |
57 | 1998 | Ridker, PM; Rifai, N; Pfeffer, MA; Sacks, FM; Moye, LA; Goldman, S; Flaker, GC; Braunwald, E | Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels | CIRCULATION | 897 |
58 | 2000 | Repa, JJ; Turley, SD; Lobaccaro, JMA; Medina, J; Li, L; Lustig, K; Shan, B; Heyman, RA; Dietschy, JM; Mangelsdorf, DJ | Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers | SCIENCE | 888 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
59 | 1995 | Anderson, TJ; Meredith, IT; Yeung, AC; Frei, B; Selwyn, AP; Ganz, P | The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion | NEW ENGLAND JOURNAL OF MEDICINE | 883 |
60 | 1972 | Carlson, LA; Bottiger, LE | Ischemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol – Stockholm prospective study | LANCET | 867 |
61 | 1991 | Stampfer, MJ; Sacks, FM; Salvini, S; Willett, WC; Hennekens, CH | A prospective-study of cholesterol, apolipoproteins, and the risk of myocardial-infarction | NEW ENGLAND JOURNAL OF MEDICINE | 865 |
62 | 1998 | Simons, M; Keller, P; De Strooper, B; Beyreuther, K; Dotti, CG; Simons, K | Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 859 |
63 | 1999 | Brown, MS; Goldstein, JL | A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 853 |
64 | 1994 | Law, MR; Wald, NJ; Thompson, SG | By how much and how quickly does reduction in serum-cholesterol concentration lower risk of ischemic-heart-disease | BRITISH MEDICAL JOURNAL | 848 |
65 | 1990 | Vist, MR; Davis, JH | Phase-equilibria of cholesterol dipalmitoylphosphatidylcholine mixtures – H-2 nuclear magnetic-resonance and differential scanning calorimetry | BIOCHEMISTRY | 842 |
66 | 2004 | Altmann, SW; Davis, HR; Zhu, LJ; Yao, XR; Hoos, LM; Tetzloff, G; Iyer, SPN; Maguire, M; Golovko, A; Zeng, M; Wang, LQ; Murgolo, N; Graziano, MP | Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption | SCIENCE | 828 |
67 | 1981 | Brown, MS; Kovanen, PT; Goldstein, JL | Regulation of plasma-cholesterol by lipoprotein receptors | SCIENCE | 825 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
68 | 1990 | Mensink, RP; Katan, MB | Effect of dietary trans-fatty-acids on high-density and low-density-lipoprotein cholesterol levels in healthy-subjects | NEW ENGLAND JOURNAL OF MEDICINE | 821 |
69 | 1976 | Brown, MS; Goldstein, JL | Receptor-mediated control of cholesterol-metabolism | SCIENCE | 815 |
70 | 1997 | Carstea, ED; Morris, JA; Coleman, KG; Loftus, SK; Zhang, D; Cummings, C; Gu, J; Rosenfeld, MA; Pavan, WJ; Krizman, DB; Nagle, J; Polymeropoulos, MH; Sturley, SL; Ioannou, YA; Higgins, ME; Comly, M; Cooney, A; Brown, A; Kaneski, CR; BlanchetteMackie, EJ; Dwyer, NK; Neufeld, EB; Chang, TY; Liscum, L; Strauss, JF; Ohno, K; Zeigler, M; Carmi, R; Sokol, J; Markie, D; ONeill, RR; vanDiggelen, OP; Elleder, M; Patterson, MC; Brady, RO; Vanier, MT; Pentchev, PG; Tagle, DA | Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis | SCIENCE | 797 |
70 | 1996 | Porter, JA; Young, KE; Beachy, PA | Cholesterol modification of hedgehog signaling proteins in animal development | SCIENCE | 797 |
72 | 1983 | Siedel, J; Hagele, EO; Ziegenhorn, J; Wahlefeld, AW | Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency | CLINICAL CHEMISTRY | 792 |
73 | 2003 | Law, MR; Wald, NJ; Rudnicka, AR | Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis | BRITISH MEDICAL JOURNAL | 786 |
74 | 2001 | Chawla, A; Boisvert, WA; Lee, CH; Laffitte, BA; Barak, Y; Joseph, SB; Liao, D; Nagy, L; Edwards, PA; Curtiss, LK; Evans, RM; Tontonoz, P | A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis | MOLECULAR CELL | 785 |
74 | 1990 | Muldoon, MF; Manuck, SB; Matthews, KA | Lowering cholesterol concentrations and mortality: A quantitative review of primary prevention trials | BRITISH MEDICAL JOURNAL | 785 |
76 | 1968 | Ladbrook, BD; Williams, RM; Chapman, D | Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction | BIOCHIMICA ET BIOPHYSICA ACTA | 783 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
77 | 1987 | Anderson, KM; Castelli, WP; Levy, D | Cholesterol and mortality – 30 years of follow-up from the framingham-study | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 781 |
78 | 1973 | Papahadj, D; Jacobson, K; Nir, S; Isac, T | Phase-transitions in phospholipid vesicles – Fluorescence polarization and permeability measurements concerning effect of temperature and cholesterol | BIOCHIMICA ET BIOPHYSICA ACTA | 780 |
79 | 1965 | Keys, A; Anderson, JT; Grande, F | Serum cholesterol response to changes in diet.4. particular saturated fatty acids in diet | METABOLISM | 772 |
80 | 2000 | Simons, K; Ikonen, E | Cell biology – How cells handle cholesterol | SCIENCE | 766 |
81 | 2005 | Nissen, SE; Tuzcu, EM; Schoenhagen, P; Crowe, T; Sasiela, WJ; Tsai, J; Orazem, J; Magorien, RD; O’Shaughnessy, C; Ganz, P | Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease | NEW ENGLAND JOURNAL OF MEDICINE | 761 |
81 | 1991 | Kazlauskas, RJ; Weissfloch, ANE; Rappaport, AT; Cuccia, LA | A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from pseudomonas-cepacia, and lipase from candida-rugosa | JOURNAL OF ORGANIC CHEMISTRY | 761 |
83 | 2007 | Lewington, S; Whitlock, G; Clarke, R; Sherliker, P; Emberson, J; Halsey, J; Qizilbash, N; Peto, R; Collins, R | Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths | LANCET | 758 |
84 | 2010 | Duewell, P; Kono, H; Rayner, KJ; Sirois, CM; Vladimer, G; Bauernfeind, FG; Abela, GS; Franchi, L; Nunez, G; Schnurr, M; Espevik, T; Lien, E; Fitzgerald, KA; Rock, KL; Moore, KJ; Wright, SD; Hornung, V; Latz, E | NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals | NATURE | 757 |
84 | 2001 | Mauch, DH; Nagler, K; Schumacher, S; Goritz, C; Muller, EC; Otto, A; Pfrieger, FW | CNS synaptogenesis promoted by glia-derived cholesterol | SCIENCE | 757 |
86 | 2011 | Boden, WE; Probstfield, JL; Anderson, T; Chaitman, BR; Desvignes-Nickens, P; Koprowicz, K; McBride, R; Teo, K; Weintraub, W | Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy | NEW ENGLAND JOURNAL OF MEDICINE | 755 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
86 | 1957 | Zak, B | Simple rapid microtechnic for serum total cholesterol | AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 755 |
88 | 2001 | Oliver, WR; Shenk, JL; Snaith, MR; Russell, CS; Plunket, KD; Bodkin, NL; Lewis, MC; Winegar, DA; Sznaidman, ML; Lambert, MH; Xu, HE; Sternbach, DD; Kliewer, SA; Hansen, BC; Willson, TM | A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 753 |
89 | 1978 | Carey, MC | Critical tables for calculating cholesterol saturation of native bile | JOURNAL OF LIPID RESEARCH | 750 |
90 | 1999 | Brown, L; Rosner, B; Willett, WW; Sacks, FM | Cholesterol-lowering effects of dietary fiber: A meta-analysis | AMERICAN JOURNAL OF CLINICAL NUTRITION | 737 |
91 | 2000 | Pearson, TA; Laurora, I; Chu, H; Kafonek, S | The Lipid Treatment Assessment Project (L-TAP) – A multicenter survey to evaluate the percentages of dyslipidemic, patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals | ARCHIVES OF INTERNAL MEDICINE | 725 |
92 | 1953 | Pearson, S; Stern, S; Mcgavack, TH | A rapid, accurate method for the determination of total cholesterol in serum | ANALYTICAL CHEMISTRY | 724 |
93 | 1983 | Mahley, RW; Innerarity, TL | Lipoprotein receptors and cholesterol homeostasis | BIOCHIMICA ET BIOPHYSICA ACTA | 722 |
94 | 2001 | Ridker, PM; Stampfer, MJ; Rifai, N | Novel risk factors for systemic atherosclerosis – A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 719 |
95 | 1989 | Iso, H; Jacobs, DR; Wentworth, D; Neaton, JD; Cohen, JD | Serum-cholesterol levels and 6-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial | NEW ENGLAND JOURNAL OF MEDICINE | 717 |
Table 1
Rank | Year | Authors | Title | Journal | Times cited |
96 | 2008 | Kathiresan, S; Melander, O; Guiducci, C; Surti, A; Burtt, NP; Rieder, MJ; Cooper, GM; Roos, C; Voight, BF; Havulinna, AS; Wahlstrand, B; Hedner, T; Corella, D; Tai, ES; Ordovas, JM; Berglund, G; Vartiainen, E; Jousilahti, P; Hedblad, B; Taskinen, MR; Newton-Cheh, C; Salomaa, V; Peltonen, L; Groop, L; Altshuler, DM; Orho-Melander, M | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | NATURE GENETICS | 715 |
97 | 2011 | Baigent, C; Landray, MJ; Reith, C; Emberson, J; Wheeler, DC; Tomson, C; Wanner, C; Krane, V; Cass, A; Craig, J; Neal, B; Jiang, LX; Hooi, LS; Levin, A; Agodoa, L; Gaziano, M; Kasiske, B; Walker, R; Massy, ZA; Feldt-Rasmussen, B; Krairittichai, U; Ophascharoensuk, V; Fellstrom, B; Holdaas, H; Tesar, V; Wiecek, A; Grobbee, D; de Zeeuw, D; Gronhagen-Riska, C; Dasgupta, T; Lewis, D; Herrington, W; Mafham, M; Majoni, W; Wallendszus, K; Grimm, R; Pedersen, T; Tobert, J; Armitage, J; Baxter, A; Bray, C; Chen, YP; Chen, ZM; Hill, M; Knott, C; Parish, S; Simpson, D; Sleight, P; Young, A; Collins, R | The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial | LANCET | 711 |
97 | 2001 | Chinetti, G; Lestavel, S; Bocher, V; Remaley, AT; Neve, B; Torra, IP; Teissier, E; Minnich, A; Jaye, M; Duverger, N; Brewer, HB; Fruchart, JC; Clavey, V; Staels, B | PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway | NATURE MEDICINE | 711 |
99 | 1960 | Burstein, M; Samaille, J | Sur un dosage rapide du cholesterol lie aux alpha-lipoproteines et aux beta-lipoproteines du serum | CLINICA CHIMICA ACTA | 706 |
100 | 1969 | Hinckley, CC | Paramagnetic shifts in solutions of cholesterol and dipyridine adduct of trisdipivalomethanatoeuropium(III). A shift reagent | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 700 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
1 | 2010 | Baigent, C; Blackwell, L; Emberson, J; Holland, LE; Reith, C; Bhala, N; Peto, R; Barnes, EH; Keech, A; Simes, J; Collins, R | Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials | LANCET | 1228 |
2 | 2011 | Boden, WE; Probstfield, JL; Anderson, T; Chaitman, BR; Desvignes-Nickens, P; Koprowicz, K; McBride, R; Teo, K; Weintraub, W | Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy | NEW ENGLAND JOURNAL OF MEDICINE | 797 |
3 | 2010 | Duewell, P; Kono, H; Rayner, KJ; Sirois, CM; Vladimer, G; Bauernfeind, FG; Abela, GS; Franchi, L; Nunez, G; Schnurr, M; Espevik, T; Lien, E; Fitzgerald, KA; Rock, KL; Moore, KJ; Wright, SD; Hornung, V; Latz, E | NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals | NATURE | 790 |
4 | 2007 | Lewington, S; Whitlock, G; Clarke, R; Sherliker, P; Emberson, J; Halsey, J; Qizilbash, N; Peto, R; Collins, R | Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths | LANCET | 776 |
5 | 2011 | Baigent, C; Landray, MJ; Reith, C; Emberson, J; Wheeler, DC; Tomson, C; Wanner, C; Krane, V; Cass, A; Craig, J; Neal, B; Jiang, LX; Hooi, LS; Levin, A; Agodoa, L; Gaziano, M; Kasiske, B; Walker, R; Massy, ZA; Feldt-Rasmussen, B; Krairittichai, U; Ophascharoensuk, V; Fellstrom, B; Holdaas, H; Tesar, V; Wiecek, A; Grobbee, D; de Zeeuw, D; Gronhagen-Riska, C; Dasgupta, T; Lewis, D; Herrington, W; Mafham, M; Majoni, W; Wallendszus, K; Grimm, R; Pedersen, T; Tobert, J; Armitage, J; Baxter, A; Bray, C; Chen, YP; Chen, ZM; Hill, M; Knott, C; Parish, S; Simpson, D; Sleight, P; Young, A; Collins, R | The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial | LANCET | 739 |
6 | 2008 | Kathiresan, S; Melander, O; Guiducci, C; Surti, A; Burtt, NP; Rieder, MJ; Cooper, GM; Roos, C; Voight, BF; Havulinna, AS; Wahlstrand, B; Hedner, T; Corella, D; Tai, ES; Ordovas, JM; Berglund, G; Vartiainen, E; Jousilahti, P; Hedblad, B; Taskinen, MR; Newton-Cheh, C; Salomaa, V; Peltonen, L; Groop, L; Altshuler, DM; Orho-Melander, M | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | NATURE GENETICS | 731 |
7 | 2007 | Barter, P; Gotto, AM; LaRosa, JC; Maroni, J; Szarek, M; Grundy, SM; Kastelein, JJP; Bittner, V; Fruchart, JC | HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events | NEW ENGLAND JOURNAL OF MEDICINE | 710 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
8 | 2008 | Kearney, PM; Blackwell, L; Collins, R; Keech, A; Simes, J; Peto, R; Armitage, J; Baigent, C | Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: A meta-analysis | LANCET | 647 |
9 | 2011 | Khera, AV; Cuchel, M; de la Llera-Moya, M; Rodrigues, A; Burke, MF; Jafri, K; French, BC; Phillips, JA; Mucksavage, ML; Wilensky, RL; Mohler, ER; Rothblat, GH; Rader, DJ | Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis | NEW ENGLAND JOURNAL OF MEDICINE | 625 |
10 | 2012 | Voight, BF; Peloso, GM; Orho-Melander, M; Frikke-Schmidt, R; Barbalic, M; Jensen, MK; Hindy, G; Holm, H; Ding, EL; Johnson, T; Schunkert, H; Samani, NJ; Clarke, R; Hopewell, JC; Thompson, JF; Li, MY; Thorleifsson, G; Newton-Cheh, C; Musunuru, K; Pirruccello, JP; Saleheen, D; Chen, L; Stewart, AFR; Schillert, A; Thorsteinsdottir, U; Thorgeirsson, G; Anand, S; Engert, JC; Morgan, T; Spertus, J; Stoll, M; Berger, K; Martinelli, N; Girelli, D; McKeown, PP; Patterson, CC; Epstein, SE; Devaney, J; Burnett, MS; Mooser, V; Ripatti, S; Surakka, I; Nieminen, MS; Sinisalo, J; Lokki, ML; Perola, M; Havulinna, A; de Faire, U; Gigante, B; Ingelsson, E; Zeller, T; Wild, P; de Bakker, PIW; Klungel, OH; Maitland-van der Zee, AH; Peters, BJM; de Boer, A; Grobbee, DE; Kamphuisen, PW; Deneer, VHM; Elbers, CC; Onland-Moret, NC; Hofker, MH; Wijmenga, C; Verschuren, WMM; Boer, JMA; van der Schouw, YT; Rasheed, A; Frossard, P; Demissie, S; Willer, C; Do, R; Ordovas, JM; Abecasis, GR; Boehnke, M; Mohlke, KL; Daly, MJ; Guiducci, C; Burtt, NP; Surti, A; Gonzalez, E; Purcell, S; Gabriel, S; Marrugat, J; Peden, J; Erdmann, J; Diemert, P; Willenborg, C; Konig, IR; Fischer, M; Hengstenberg, C; Ziegler, A; Buysschaert, I; Lambrechts, D; Van de Werf, F; Fox, KA; El Mokhtari, NE; Rubin, D; Schrezenmeir, J; Schreiber, S; Schafer, A; Danesh, J; Blankenberg, S; Roberts, R; McPherson, R; Watkins, H; Hall, AS; Overvad, K; Rimm, E; Boerwinkle, E; Tybjaerg-Hansen, A; Cupples, LA; Reilly, MP; Melander, O; Mannucci, PM; | Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study | LANCET | 535 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Ardissino, D; Siscovick, D; Elosua, R; Stefansson, K; O’Donnell, CJ; Salomaa, V; Rader, DJ; Peltonen, L; Schwartz, SM; Altshuler, D; Kathiresan, S | |||||
11 | 2014 | Stone, NJ; Robinson, JG; Lichtenstein, AH; Merz, CNB; Blum, CB; Eckel, RH; Goldberg, AC; Gordon, D; Levy, D; Lloyd-Jones, DM; McBride, P; Schwartz, JS; Shero, ST; Smith, SC; Watson, K; Wilson, PWF | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines | CIRCULATION | 533 |
12 | 2012 | Mihaylova, B; Emberson, J; Blackwell, L; Keech, A; Simes, J; Barnes, EH; Voysey, M; Gray, A; Collins, R; Baigent, C; de Lemos, J; Braunwald, E; Blazing, M; Murphy, S; Downs, JR; Gotto, A; Clearfield, M; Holdaas, H; Gordon, D; Davis, B; Koren, M; Dahlof, B; Poulter, N; Sever, P; Knopp, RH; Fellstrom, B; Holdaas, H; Jardine, A; Schmieder, R; Zannad, F; Goldbourt, U; Kaplinsky, E; Colhoun, HM; Betteridge, DJ; Durrington, PN; Hitman, GA; Fuller, J; Neil, A; Wanner, C; Krane, V; Sacks, F; Moye, L; Pfeffer, M; Hawkins, CM; Braunwald, E; Kjekshus, J; Wedel, H; Wikstrand, J; Barter, P; Keech, A; Tavazzi, L; Maggioni, A; Marchioli, R; Tognoni, G; Franzosi, MG; Maggioni, A; Bloomfield, H; Robins, S; Collins, R; Armitage, J; Keech, A; Parish, S; Peto, R; Sleight, P; Pedersen, TR; Ridker, PM; Holman, R; Meade, T; Simes, J; Keech, A; MacMahon, S; Marschner, I; Tonkin, A; Shaw, J; Serruys, PW; Nakamura, H; Knatterud, G; Furberg, C; Byington, R; Macfarlane, P; Cobbe, S; Ford, I; Murphy, M; Blauw, GJ; Packard, C; Shepherd, J; Kjekshus, J; Pedersen, T; Wilhelmsen, L; Braunwald, E; Cannon, C; Murphy, S; Collins, R; Armitage, J; Bowman, L; Parish, S; Peto, R; Sleight, P; Baigent, C; Landray, M; Collins, R; La Rosa, J; Rossouw, J; Probstfield, J; Shepherd, J; Cobbe, S; Macfarlane, P; Ford, I | The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials | LANCET | 496 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
13 | 2014 | Stone, NJ; Robinson, JG; Lichtenstein, AH; Merz, CNB; Blum, CB; Eckel, RH; Goldberg, AC; Gordon, D; Levy, D; Lloyd-Jones, DM; McBride, P; Schwartz, JS; Shero, ST; Smith, SC; Watson, K; Wilson, PWF | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 475 |
14 | 2009 | Ridker, PM; Danielson, E; Fonseca, FAH; Genest, J; Gotto, AM; Kastelein, JJP; Koenig, W; Libby, P; Lorenzatti, AJ; MacFadyen, JG; Nordestgaard, BG; Shepherd, J; Willerson, JT; Glynn, RJ | Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial | LANCET | 453 |
15 | 2008 | Hanson, MA; Cherezov, V; Griffith, MT; Roth, CB; Jaakola, VP; Chien, EYT; Velasquez, J; Kuhn, P; Stevens, RC | A specific cholesterol binding site is established by the 2.8 angstrom structure of the human beta(2)-adrenergic receptor | STRUCTURE | 435 |
16 | 2010 | Rayner, KJ; Suarez, Y; Davalos, A; Parathath, S; Fitzgerald, ML; Tamehiro, N; Fisher, EA; Moore, KJ; Fernandez-Hernando, C | MiR-33 Contributes to the Regulation of Cholesterol Homeostasis | SCIENCE | 414 |
17 | 2008 | Ikonen, E | Cellular cholesterol trafficking and compartmentalization | NATURE REVIEWS MOLECULAR CELL BIOLOGY | 377 |
18 | 2008 | Kathiresan, S; Melander, O; Anevski, D; Guiducci, C; Burtt, NP; Roos, C; Hirschhorn, JN; Berglund, G; Hedblad, B; Groop, L; Altshuler, DM; Newton-Cheh, C; Orho-Melander, M | Polymorphisms associated with cholesterol and risk of cardiovascular events | NEW ENGLAND JOURNAL OF MEDICINE | 367 |
19 | 2007 | Nicholls, SJ; Tuzcu, EM; Sipahi, I; Grasso, AW; Schoenhagen, P; Hu, T; Wolski, K; Crowe, T; Desai, MY; Hazen, SL; Kapadia, SR; Nissen, SE | Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 363 |
20 | 2010 | Musunuru, K; Strong, A; Frank-Kamenetsky, M; Lee, NE; Ahfeldt, T; Sachs, KV; Li, XY; Li, H; Kuperwasser, N; Ruda, VM; Pirruccello, JP; Muchmore, B; Prokunina-Olsson, L; Hall, JL; Schadt, EE; Morales, CR; Lund-Katz, S; Phillips, MC; Wong, J; Cantley, W; Racie, T; Ejebe, KG; | From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus | NATURE | 361 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Orho-Melander, M; Melander, O; Koteliansky, V; Fitzgerald, K; Krauss, RM; Cowan, CA; Kathiresan, S; Rader, DJ | |||||
21 | 2007 | Zidovetzki, R; Levitan, I | Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 336 |
22 | 2010 | Najafi-Shoushtari, SH; Kristo, F; Li, YX; Shioda, T; Cohen, DE; Gerszten, RE; Naar, AM | MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis | SCIENCE | 333 |
23 | 2006 | Lee, JK; Grace, KA; Taylor, AJ | Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol – A randomized controlled trial | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 328 |
24 | 2010 | Raal, FJ; Santos, RD; Blom, DJ; Marais, AD; Charng, MJ; Cromwell, WC; Lachmann, RH; Gaudet, D; Tan, JL; Chasan-Taber, S; Tribble, DL; Flaim, JD; Crooke, ST | Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial | LANCET | 307 |
25 | 2011 | Chapman, MJ; Ginsberg, HN; Amarenco, P; Andreotti, F; Boren, J; Catapano, AL; Descamps, OS; Fisher, E; Kovanen, PT; Kuivenhoven, JA; Lesnik, P; Masana, L; Nordestgaard, BG; Ray, KK; Reiner, Z; Taskinen, MR; Tokgozoglu, L; Tybjaerg-Hansen, A; Watts, GF | Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management | EUROPEAN HEART JOURNAL | 302 |
26 | 2008 | Frank-Kamenetsky, M; Grefhorst, A; Anderson, NN; Racie, TS; Bramlage, B; Akinc, A; Butler, D; Charisse, K; Dorkin, R; Fan, Y; Gamba-Vitalo, C; Hadwiger, P; Jayaraman, M; John, M; Jayaprakash, KN; Maier, M; Nechev, L; Rajeev, KG; Read, T; Rohl, I; Soutschek, J; Tan, P; Wong, J; Wang, G; Zimmermann, T; de Fougerolles, A; Vornlocher, HP; Langer, R; Anderson, DG; Manoharan, M; Koteliansky, V; Horton, JD; Fitzgerald, K | Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 289 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
26 | 2006 | Kalaany, NY; Mangelsdorf, DJ | LXRs and FXR: The Yin and Yang of cholesterol and fat metabolism | ANNUAL REVIEW OF PHYSIOLOGY | 289 |
28 | 2008 | Pandey, AK; Sassetti, CM | Mycobacterial persistance requires the utilization of host cholesterol | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 285 |
28 | 2007 | Wang, X; Collins, HL; Ranalletta, M; Fuki, IV; Billheimer, JT; Rothblat, GH; Tall, AR; Rader, DJ | Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo | JOURNAL OF CLINICAL INVESTIGATION | 285 |
30 | 2006 | Kotowski, IK; Pertsemlidis, A; Luke, A; Cooper, RS; Vega, GL; Cohen, JC; Hobbs, HH | A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol | AMERICAN JOURNAL OF HUMAN GENETICS | 274 |
31 | 2012 | Stein, EA; Mellis, S; Yancopoulos, GD; Stahl, N; Logan, D; Smith, WB; Lisbon, E; Gutierrez, M; Webb, C; Wu, R; Du, YL; Kranz, T; Gasparino, E; Swergold, GD | Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol | NEW ENGLAND JOURNAL OF MEDICINE | 267 |
32 | 2009 | Zelcer, N; Hong, C; Boyadjian, R; Tontonoz, P | LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor | SCIENCE | 266 |
32 | 2007 | Lorenzo, C; Williams, K; Hunt, KJ; Haffner, SM | The National Cholesterol Education Program-Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes | DIABETES CARE | 266 |
34 | 2010 | Klaassen, CD; Aleksunes, LM | Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation | PHARMACOLOGICAL REVIEWS | 265 |
35 | 2011 | Carette, JE; Raaben, M; Wong, AC; Herbert, AS; Obernosterer, G; Mulherkar, N; Kuehne, AI; Kranzusch, PJ; Griffin, AM; Ruthel, G; Dal Cin, P; Dye, JM; Whelan, SP; Chandran, K; Brummelkamp, TR | Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 | NATURE | 259 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
36 | 2006 | Cuchel, M; Rader, DJ | Macrophage reverse cholesterol transport – Key to the regression of atherosclerosis? | CIRCULATION | 249 |
37 | 2012 | Stein, EA; Gipe, D; Bergeron, J; Gaudet, D; Weiss, R; Dufour, R; Wu, R; Pordy, R | Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial | LANCET | 243 |
38 | 2010 | Rajamaki, K; Lappalainen, J; Oorni, K; Valimaki, E; Matikainen, S; Kovanen, PT; Eklund, KK | Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation | PLOS ONE | 242 |
38 | 2006 | Shepherd, J; Breazna, A; Barter, P; LaRosa, J; Carmena, R; Grundy, S; Deedwania, P; Waters, D; Fruchart, JC; Haffner, S; Hsia, J | Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes – The treating to new targets (TNT) study | DIABETES CARE | 242 |
40 | 2006 | Barter, PJ; Ballantyne, CM; Carmena, R; Cabezas, MC; Chapman, MJ; Couture, P; De Graaf, J; Durrington, PN; Faergeman, O; Frohlich, J; Furberg, CD; Gagne, C; Haffner, SM; Humphries, SE; Jungner, I; Krauss, RM; Kwiterovich, P; Marcovina, S; Packard, CJ; Pearson, TA; Reddy, KS; Rosenson, R; Sarrafzadegan, N; Sniderman, AD; Stalenhoef, AF; Stein, E; Talmud, PJ; Tonkin, AM; Walldius, G; Williams, KMS | Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: Report of the thirty-person/ten-country panel | JOURNAL OF INTERNAL MEDICINE | 238 |
41 | 2012 | Rosenson, RS; Brewer, HB; Davidson, WS; Fayad, ZA; Fuster, V; Goldstein, J; Hellerstein, M; Jiang, XC; Phillips, MC; Rader, DJ; Remaley, AT; Rothblat, GH; Tall, AR; Yvan-Charvet, L | Cholesterol Efflux and Atheroprotection Advancing the Concept of Reverse Cholesterol Transport | CIRCULATION | 236 |
42 | 2008 | Tall, AR; Yvan-Charvet, L; Terasaka, N; Pagler, T; Wang, N | HDL, ABC transporters, and cholesterol efflux: Implications for the treatment of atherosclerosis | CELL METABOLISM | 235 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
43 | 2011 | Rayner, KJ; Sheedy, FJ; Esau, CC; Hussain, FN; Temel, RE; Parathath, S; van Gils, JM; Rayner, AJ; Chang, AN; Suarez, Y; Fernandez-Hernando, C; Fisher, EA; Moore, KJ | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis | JOURNAL OF CLINICAL INVESTIGATION | 230 |
44 | 2006 | Gelissen, IC; Harris, M; Rye, KA; Quinn, C; Brown, AJ; Kockx, M; Cartland, S; Packianathan, M; Kritharides, L; Jessup, W | ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 227 |
44 | 2006 | Chang, TY; Chang, CCY; Ohgami, N; Yamauchi, Y | Cholesterol sensing, trafficking, and esterification | ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 227 |
46 | 2008 | Tall, AR | Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins | JOURNAL OF INTERNAL MEDICINE | 221 |
46 | 2006 | Mari, M; Caballero, F; Colell, A; Morales, A; Caballeria, J; Fernandez, A; Enrich, C; Fernandez-Checa, JC; Garcia-Ruiz, C | Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis | CELL METABOLISM | 221 |
48 | 2006 | Naik, SU; Wang, X; Da Silva, JS; Jaye, M; Macphee, CH; Reilly, MP; Billheimer, JT; Rothblat, GH; Rader, DJ | Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo | CIRCULATION | 220 |
49 | 2009 | Briel, M; Ferreira-Gonzalez, I; You, JJ; Karanicolas, PJ; Akl, EA; Wu, P; Blechacz, B; Bassler, D; Wei, XG; Sharman, A; Whitt, I; da Silva, SA; Khalid, Z; Nordmann, AJ; Zhou, Q; Walter, SD; Vale, N; Bhatnagar, N; O’Regan, C; Mills, EJ; Bucher, HC; Montori, VM; Guyatt, GH | Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: Systematic review and meta-regression analysis | BRITISH MEDICAL JOURNAL | 218 |
50 | 2007 | Akuta, N; Suzuki, F; Kawamura, Y; Yatsuji, H; Sezaki, H; Suzuki, Y; Hosaka, T; Kobayashi, M; Kobayashi, M; Arase, Y; Ikeda, K; Kumada, H | Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: Amino acid substitutions in the core region and low-density lipoprotein cholesterol levels | JOURNAL OF HEPATOLOGY | 217 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
50 | 2007 | Van der Geize, R; Yam, K; Heuser, T; Wilbrink, MH; Hara, H; Anderton, MC; Sim, E; Dijkhuizen, L; Davies, JE; Mohn, WW; Eltis, LD | A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 217 |
52 | 2006 | Oram, JF; Vaughan, AM | ATP-binding cassette cholesterol transporters and cardiovascular disease | CIRCULATION RESEARCH | 215 |
53 | 2008 | Frikke-Schmidt, R; Nordestgaard, BG; Stene, MCA; Sethi, AA; Remaley, AT; Schnohr, P; Grande, P; Tybjaerg-Hansen, A | Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 214 |
54 | 2008 | Sandhu, MS; Waterworth, DM; Debenham, SL; Wheeler, E; Papadakis, K; Zhao, JH; Song, KJ; Yuan, X; Johnson, T; Ashford, S; Inouye, M; Luben, R; Sims, M; Hadley, D; McArdle, W; Barter, P; Kesaniemi, YA; Mahley, RW; McPherson, R; Grundy, SM; Bingham, SA; Khaw, KT; Loos, RJF; Waeber, G; Barroso, I; Strachan, DP; Deloukas, P; Vollenweider, P; Wareham, NJ; Mooser, V | LDL-cholesterol concentrations: A genome-wide association study | LANCET | 210 |
54 | 2006 | Deedwania, P; Barter, P; Carmena, R; Fruchart, JC; Grundy, SM; Haffner, S; Kastelein, JJP; LaRosa, JC; Schachner, H; Shepherd, J; Waters, DD | Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: Analysis of the Treating to New Targets study | LANCET | 210 |
56 | 2011 | Griffin, JE; Gawronski, JD; DeJesus, MA; Ioerger, TR; Akerley, BJ; Sassetti, CM | High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism | PLOS PATHOGENS | 208 |
56 | 2007 | Mehta, JL; Sanada, N; Hu, CP; Chen, JW; Dandapat, A; Sugawara, F; Satoh, H; Inoue, K; Kawase, Y; Jishage, K; Suzuki, H; Takeya, M; Schnackenberg, L; Beger, R; Hermonat, PL; Thomas, M; Sawamura, T | Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet | CIRCULATION RESEARCH | 208 |
58 | 2012 | Raal, F; Scott, R; Somaratne, R; Bridges, I; Li, G; Wasserman, SM; Stein, EA | Low-Density Lipoprotein Cholesterol-Lowering Effects of AMG 145, a Monoclonal Antibody to | CIRCULATION | 206 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients with Heterozygous Familial Hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) Randomized Trial | |||||
59 | 2011 | Nicholls, SJ; Brewer, HB; Kastelein, JJP; Krueger, KA; Wang, MD; Shao, MY; Hu, B; McErlean, E; Nissen, SE | Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination with Statins on HDL and LDL Cholesterol A Randomized Controlled Trial | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 204 |
60 | 2008 | Miller, M; Cannon, CP; Murphy, SA; Qin, J; Ray, KK; Braunwald, E | Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 203 |
61 | 2012 | Sainz, B; Barretto, N; Martin, DN; Hiraga, N; Imamura, M; Hussain, S; Marsh, KA; Yu, XM; Chayama, K; Alrefai, WA; Uprichard, SL | Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor | NATURE MEDICINE | 201 |
62 | 2010 | Armitage, J; Bowman, L; Wallendszus, K; Bulbulia, R; Rahimi, K; Haynes, R; Parish, S; Peto, R; Collins, R; Meade, T; Sleight, P; Collins, R; Armitage, J; Bowman, L; Parish, S; Peto, R; Barton, J; Bray, C; Wincott, E; Dayanandan, R; Clarke, R; Graham, I; Simpson, D; Warlow, C; Wilken, D; Tobert, J; Mushner, T; Doll, R; Wilhelmsen, L; Fox, K; Hill, C; Sandercock, P; Webster, J; Henderson, J; Nixon, A; Lackie, S; Thompson, J; Brown, M; Blackwood, S; Morgan, M; Rhoden, W; Saeed, B; Houghton, M; Nicholson, A; Simpson, C; Hoburn, B; Cooper, I; Gallivan, A; Pickerell, E; Hancock, J; Watkinson, J; Ryder, B; Jones, S; Burbridge, W; Kitchen, M; Leary, HO; Verow, C; Meynell, L; Rollinson, L; Bain, S; Jones, A; Jewkes, C; Russon, C; Bateson, M; Gill, P; Nicol, J; Bayly, G; | Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: A double-blind randomised trial | LANCET | 199 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Stansbie, D; Andrews, G; Halestrap, M; Meredith, J; Best, R; Appleyard, D; Briggs, R; Wareing, H; Holmes, K; Holt, J; Kenyon, M; White, C; Khalifa, M; Newton, D; Wass, A; Watkinson, R; Creamer, J; Anderson, S; Bethell, A; Butler, C; Castro, K; Washington, M; Weston, M; Cleaver, K; Machin, J; Wray, R; Sinclair, J; Van Aalst, A; Been, M; Mattu, R; Bates, D; Burke, A; Gill, L; Walton, E; Cowley, M; Robson, H; Graham, A; Rose, G; Kerr, M; Mallinson, J; Peascod, B; Donnelly, R; Kalk, J; Scott, A; Gibson, T; Hannah, J; Henshaw, L; Margetts, M; Pearson, N; Frost, S; Murray, S; Marshall, A; Went, J; Inman, A; Simmonds, J; Teasdale, A; Kemp, T; Roberts, G; Kooner, J; Cahill, S; Lloyd, M; Molloy, O; Wigley, J; Galvin, M; Wilder, C; Lindley, R; Shaw, S; Swainson, C; Hillis, L; Johnston, J; Johnstone, A; Miller, D; Kennedy, M; Mushahwar, S; Savage, M; Appleyard, D; Ayer, G; Schofield, J; Greenhalgh, S; Parks, J; Speak, S; Coulson, C; Papouchado, M; Carpenter, R; Wisby, J; Cobbe, S; Campbell, C; Hunter, J; Young, H; Gallacher, M; Lindsay, D; Halliday, A; Godfrey, S; Donahoo, LO; Chambers, J; Wierzbicki, A; Jones, A; Parkin, D; Nwafor, K; Oldroyd, K; Vallance, B; Cunningham, N; Moreland, G; Oldroyd, C; Young, H; Crawford, M; Hillson, R; Knott, K; Mahabir, N; Crouch, A; MacDonald, Y; Bellamy, C; Green, J; Brown, L; Heron, J; Jones, N; Roberts, M; Hainsworth, D; Williams, J; Barnes, P; Fitchet, A; Longworth, C; Davidson, J; Irvine, N; Oliver, R; Pond, C; Nuttall, M; Mostyn, RL; Brown, M; Barrowcliffe, J; Blackburn, S; Furnell, W; Webster, S; Wheatley, L; Hudson, I; Pohl, J; Nicholson, S; Mallya, S; Nash, M; Spruce, J; Bonner, A; Leather, J; Searle, A; Davies, E; Egdell, R; Price, B; Bennett, AT; Horton, S; Cunnington, A; Giles, P; Sidaway, J; Tomlinson, L; Walton, E; Hawkins, L; Long, J; Murphy, J; Brennan, G; Boon, M; Cassidy, S; Rodger, C; Hunter, J; McNeilly, A; Moreland, G; Radcliffe, A; Farrer, M; Bluett, J; Cowell, L; Farrell, A; Gilroy, S; |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Warren, S; MacConnell, T; Burtchaell, S; Williams, L; Rylance, P; Hodgson, A; Hill, KK; Robinson, L; Smallwood, A; Lomas, S; Ball, J; Benbow, S; Hardy, K; Gerrard, M; Langley, C; Beattie, M; Fagan, C; Green, B; Pringle, T; Hanna, H; Mackintosh, A; Watson, E; Swan, J; Appleyard, D; McSorland, D; Thompson, G; Neill, CO; Curless, R; Doig, C; McKenna, P; Martin, J; Murdy, J; Scott, A; Martin, S; Birkhead, J; Donnell, JO; Fox, C; Dixon, S; Hassall, A; Tanqueray, E; Vass, D; Cosford, I; Elderkin, M; McKenzie, P; Gray, T; Appleyard, D; Holmshaw, N; McKinnon, A; Bennett, AT; Ali, I; Stephens, N; Banfield, A; Chester, L; Wiseman, J; Harrisingh, N; Patel, R; Thaker, P; Armitage, J; Watkins, H; Beebe, S; Fitzgerald, J; Godden, J; Lawson, A; Lochhead, H; Taylor, A; Turner, S; Rowlands, D; Cooper, A; Graham, J; Hennessy, S; Rashid, T; Smith, C; Nyman, C; Adams, J; Hardwick, A; Buck, P; Pattinson, C; Trigg, J; McLeod, A; Gardner, S; Haimes, L; Orr, S; Johns, S; Capps, N; Cook, A; Donaldson, D; Keighley, C; Stiles, C; Asbridge, S; Buller, N; Townend, J; Hooks, J; Jewkes, C; Jones, H; Watson, R; Salt, P; Francis, M; MacLeod, D; Allcoat, P; Stuart, R; Reynolds, T; Maiden, J; Reynolds, J; Murray, D; MacFadyen, R; Potts, L; Smith, A; King, L; Muthusamy, R; Jones, M; Lawan, M; Nixon, J; Wasnidge, L; Weston, C; Hutchesson, A; Evans, J; Morris, K; Oultram, M; Armitage, M; Skule, R; Cope, C; Page, M; Fleming, S; Andain, K; Parrett, M; Soper, R; MacLeod, K; Gordon, K; Green, E; Havill, S; Stewart, V; Allen, S; Henson, S; Rimmer, C; Davies, J; Javed, M; Norris, A; Williams, M; Khan, S; Dobie, G; Fitton, J; Gilbert, S; Davenport, C; Williamson, M; Vincent, R; Joyce, E; Reckless, J; Bishop, A; Brice, L; Carpenter, R; Field, P; Shute, C; Pope, S; Stacey, D; Findlay, I; Campbell, C; Hunter, J; Gallacher, M; Labib, M; Hodgson, A; Sidaway, J; Beddoe, L; Reed, J; Barron, J; Odemuyiwa, O; Bradford, B; McDonnell, M; West, L; |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Beck, P; Gilbey, S; Clarkson, A; Drury, K; Hall, S; Quartey, D; Whittam, B; Lund, D; Stott, L; Griffiths, H; Appleyard, D; Fitzgerald, J; Kudarenko, A; Watkins, J; Golledge, S; Pottle, J; Little, S; Paine, B; Shears, C; Baxter, M; Wilkinson, P; Chambers, R; Hamper, C; Hollister, E; Ramsay, H; Barber, J; Hopkins, T; Hughes, L; Whittaker, JE; Verow, C; Burke, RL; Lloyd, C; Dhawan, J; John, J; Bramley, D; Catchpole, A; Colecchia, A; Gray, C; LeQuelenec, M; Remington, D; Wiseman, J; Gray, C; Anderson, P; Woolass, R; Thomas, P; Weston, C; Guy, F; Lynch, J; Thomas, R; Coates, S; Gait, M; Waller, D; Elkins, K; Franklin, M; Moore, L; Signy, M; Chilton, R; Joyce, E; Wrapson, C; Wiltshire, C; Lewis, P; Curtis, J; Toole, JO; Scanlon, S; Carey, C; Dobson, L; Gould, M; Mansfield, H; Ranson, G; Rodaway, M; Germon, J; Cockcroft, J; McDowell, I; Field, R; Whiting, J; Dennison, C; Roberts, D; Cooper, M; Davies, C; Fitton, J; Hutt, L; Radford, L; Ward, L; Williamson, M; McAlpine, H; Dougall, H; Robertson, L; Scott, L; Young, H; Humphrey, P; Saminaden, S; Watling, D; Davies, J; Owen, L; Clements, M; Walker, E; Atkins, E; Lindley, R; Shaw, T; Swainson, C; Webb, D; MacCallum, H; Markie, D; Melville, V; Adamson, L; Johnston, A; Polukord, E; Rudden, M; Hogan, J; Lie, F; Badger, V; Duffy, S; Mitchell, C; MacQueen, E; Baxter, R; Campbell, S; McDonald, L; Wood, H; Munro, A; Pycock, C; Cadwell, J; Doughty, A; Harvey, M; Price, S; Aldersley, M; Lock, S; Pendrey, P; Barton, J; Bray, C; Dayanandan, R; Wmcott, E; Achiri, P; Anderson, C; Benham, J; Bojowsky, H; Boller, I; Booker, V; Brewer, A; Brindley, G; Cobb, L; Collett, A; Corbett, M; Crowther, J; Pour, SD; Edmunds, K; Fortun, A; Grimsey, T; Harwood, C; Hope, C; Jones, R; Jones, S; Kidney, K; King, M; Knight, S; Lang, H; Madgwick, Z; Marsden, C; Matthews, C; Matthewson, M; Miller, J; Moss, B; Mostefai, Y; Murphy, K; Naughten, A; Pickworth, S; Radley, A; Southren, S; Sutherland, S; Tong, R; Turakani, M; |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Umbrath, M; Armitage, J; Baigent, C; Bowman, L; Bulbulia, R; Chen, Z; Clarke, R; Collins, R; Dunachie, S; Dasgupta, T; Haynes, R; Landray, M; Mafham, M; Majoni, W; Murray, C; Naessens, K; Porter, T; Rahimi, K; Reith, C; Clarke, MT; Turnbull, C; Walter, K; Harding, P; Lay, M; Wallendszus, K; Berry, C; Bettesworth, H; Booth, J; Bowes, M; Bu, Y; Charles, A; Cody, A; Cox, J; Emberson, J; Goodwin, N; Hurt, C; Link, E; McCabe, P; Munday, A; Murawska, A; Offer, A; Palmer, A; Parish, S; Peto, R; Prajapati, N; Tochlin, S; Young, A; Young, A; Clark, S; Kourelhas, K; Radley, M; Ambrose, V; Bradley, M; Bush, E; Chavagnon, T; Chukwurah, B; Crowley, S; Dunseath, J; Emmens, K; Fletcher, L; Gordon, J; Gordon, A; Hickman, C; Hill, J; Ji, M; Lee, A; Luker, N; Norris, S; Priestley, H; Sullivan, J; Taylor, J; Wintour, J; Yeung, M; Youngman, L; Beebe, S; Fitzgerald, J; Godden, J; Haimes, L; Lawson, A; Lochhead, H; McDonnell, M; Nash, M; Taylor, A; Bennett, AT; Walton, E | |||||
63 | 2008 | Wouters, K; van Gorp, PJ; Bieghs, V; Gijbels, MJ; Duimel, H; Lutjohann, D; Kerksiek, A; van Kruchten, R; Maeda, N; Staels, B; van Bilsen, M; Shiri-Sverdlov, R; Hofker, MH | Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis | HEPATOLOGY | 199 |
63 | 2007 | Bogers, RP; Bemelmans, WJE; Hoogenveen, RT; Boshuizen, HC; Woodward, M; Knekt, P; van Dam, RM; Hu, FB; Visscher, TLS; Menotti, A; Thorpe, RJ; Jamrozik, K; Calling, S; Strand, BH; Shipley, MJ | Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels – A meta-analysis of 21 cohort studies including more than 300,000 persons | ARCHIVES OF INTERNAL MEDICINE | 199 |
65 | 2009 | Kwon, HJ; Abi-Mosleh, L; Wang, ML; Deisenhofer, J; Goldstein, JL; Brown, MS; Infante, RE | Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol | CELL | 197 |
66 | 2009 | Demonty, I; Ras, RT; van der Kniap, HCM; Duchateau, GSMJF; Meijer, L; Zock, PL; Geleijnse, JM; Trautwein, EA | Continuous Dose-Response Relationship of the LDL-Cholesterol-Lowering Effect of Phytosterol Intake | JOURNAL OF NUTRITION | 194 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
66 | 2006 | Kastelein, JJP; Wedel, MK; Baker, BF; Su, J; Bradley, JD; Yu, RZ; Chuang, E; Graham, MJ; Crooke, RM | Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B | CIRCULATION | 194 |
66 | 2006 | Portincasa, P; Moschetta, A; Palasciano, G | Cholesterol gallstone disease | LANCET | 194 |
69 | 2007 | Zhang, YY; Guo, KY; LeBlanc, RE; Loh, D; Schwartz, GJ; Yu, YH | Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms | DIABETES | 185 |
69 | 2006 | Li, YC; Park, MJ; Ye, SK; Kim, CW; Kim, YN | Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents | AMERICAN JOURNAL OF PATHOLOGY | 185 |
71 | 2009 | Rader, DJ; Alexander, ET; Weibel, GL; Billheimer, J; Rothblat, GH | The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis | JOURNAL OF LIPID RESEARCH | 183 |
72 | 2007 | Liu, Q; Zerbinatti, CV; Zhang, J; Hoe, HS; Wang, B; Cole, SL; Herz, J; Muglia, L; Bu, GJ | Amyloid precursor protein regulates brain apolipoprotein e and cholesterol metabolism through lipoprotein receptor LRP1 | NEURON | 182 |
73 | 2006 | Matsuura, F; Wang, N; Chen, WG; Jiang, XC; Tall, AR | HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway | JOURNAL OF CLINICAL INVESTIGATION | 180 |
74 | 2009 | Brown, MS; Goldstein, JL | Cholesterol feedback: From Schoenheimer’s bottle to Scap’s MELADL | JOURNAL OF LIPID RESEARCH | 179 |
74 | 2007 | Temel, RE; Tang, WQ; Ma, YY; Rudel, LL; Willingham, MC; Ioannou, YA; Davies, JP; Nilsson, LM; Yu, LQ | Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetirnibe | JOURNAL OF CLINICAL INVESTIGATION | 179 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
76 | 2012 | Boekholdt, SM; Arsenault, BJ; Mora, S; Pedersen, TR; LaRosa, JC; Nestel, PJ; Simes, RJ; Durrington, P; Hitman, GA; Welch, KMA; DeMicco, DA; Zwinderman, AH; Clearfield, MB; Downs, JR; Tonkin, AM; Colhoun, HM; Gotto, AM; Ridker, PM; Kastelein, JJP | Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels with Risk of Cardiovascular Events Among Patients Treated with Statins A Meta-analysis | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 178 |
76 | 2011 | Di Paolo, G; Kim, TW | Linking lipids to Alzheimer’s disease: Cholesterol and beyond | NATURE REVIEWS NEUROSCIENCE | 178 |
78 | 2010 | Yvan-Charvet, L; Wang, N; Tall, AR | Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 177 |
78 | 2009 | Rog, T; Pasenkiewicz-Gierula, M; Vattulainen, I; Karttunen, M | Ordering effects of cholesterol and its analogues | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 177 |
80 | 2008 | van der Steeg, WA; Holme, I; Boekholdt, SM; Larsen, ML; Lindahl, C; Stroes, ESG; Tikkanen, MJ; Wareham, NJ; Faergeman, O; Olsson, AG; Pedersen, TR; Khaw, KT; Kastelein, JJP | High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: Significance for cardiovascular risk – The IDEAL and EPIC-Norfolk studies | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 174 |
81 | 2009 | Chan, JCY; Piper, DE; Cao, QO; Liu, DM; King, C; Wang, W; Tang, J; Liu, Q; Higbee, J; Xia, Z; Di, YM; Shetterly, S; Arimura, Z; Salomonis, H; Romanow, WG; Thibault, ST; Zhang, R; Cao, P; Yang, XP; Yu, T; Lu, M; Retter, MW; Kwon, G; Henne, K; Pan, O; Tsai, MM; Fuchslocher, B; Yang, E; Zhou, L; Lee, KJ; Daris, M; Sheng, J; Wang, Y; Shen, WD; Yeh, WC; Emery, M; Walker, NPC; Shan, B; Schwarz, M; Jackson, SM | A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 171 |
82 | 2011 | Farzadfar, F; Finucane, MM; Danaei, G; Pelizzari, PM; Cowan, MJ; Paciorek, CJ; Singh, GM; Lin, JK; Stevens, GA; Riley, LM; Ezzati, M | National, regional, and global trends in serum total cholesterol since 1980: Systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants | LANCET | 170 |
83 | 2012 | Sullivan, D; Olsson, AG; Scott, R; Kim, JB; Xue, A; Gebski, V; Wasserman, SM; | Effect of a Monoclonal Antibody to PCSK9 on | JAMA-JOURNAL OF THE | 168 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Stein, EA | Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients The GAUSS Randomized Trial | AMERICAN MEDICAL ASSOCIATION | |||
84 | 2006 | Oksman, M; Livonen, H; Hogyes, E; Amtul, Z; Penke, B; Leenders, I; Broersen, L; Lutjohann, D; Hartmann, T; Tanila, H | Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice | NEUROBIOLOGY OF DISEASE | 165 |
85 | 2007 | Kapadia, SB; Barth, H; Baumert, T; McKeating, JA; Chisari, FV | Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I | JOURNAL OF VIROLOGY | 162 |
86 | 2007 | Buch, S; Schafmayer, C; Volzke, H; Becker, C; Franke, A; von Eller-Eberstein, H; Kluck, C; Bassmann, I; Brosch, M; Lammert, F; Miquel, JF; Nervi, F; Wittig, M; Rosskopf, D; Timm, B; Holl, C; Seeger, M; ElSharawy, A; Lu, T; Egberts, J; Fandrich, F; Folsch, UR; Krawczak, M; Schreiber, S; Nurnberg, P; Tepel, J; Hampe, J | A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease | NATURE GENETICS | 161 |
87 | 2008 | Yvan-Charvet, L; Welch, C; Pagler, TA; Ranalletta, M; Lamkanfi, M; Han, S; Ishibashi, M; Li, R; Wang, N; Tall, AR | Increased Inflammatory Gene Expression in ABC Transporter-Deficient Macrophages Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions | CIRCULATION | 160 |
87 | 2008 | Infante, RE; Wang, ML; Radhakrishnan, A; Kwon, HJ; Brown, MS; Goldstein, JL | NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 160 |
87 | 2008 | Anstey, KJ; Lipnicki, DM; Low, LF | Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 160 |
90 | 2008 | Zhu, X; Lee, JY; Timmins, JM; Brown, JM; Boudyguina, E; Mulya, A; | Increased cellular free cholesterol in | JOURNAL OF BIOLOGICAL | 156 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
Gebre, AK; Willingham, MC; Hiltbold, EM; Mishra, N; Maeda, N; Parks, JS | macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages | CHEMISTRY | |||
90 | 2006 | Vaughan, AM; Oram, JF | ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL | JOURNAL OF LIPID RESEARCH | 156 |
90 | 2006 | Jessup, W; Gelissen, IC; Gaus, K; Kritharides, L | Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages | CURRENT OPINION IN LIPIDOLOGY | 156 |
93 | 2009 | Waters, DD; Brotons, C; Chiang, CW; Ferrieres, J; Foody, J; Jukema, JW; Santos, RD; Verdejo, J; Messig, M; McPherson, R; Seung, KB; Tarasenko, L | Lipid Treatment Assessment Project 2 A Multinational Survey to Evaluate the Proportion of Patients Achieving Low-Density Lipoprotein Cholesterol Goals | CIRCULATION | 155 |
94 | 2006 | Martins, IJ; Hone, E; Foster, JK; Sunram-Lea, SI; Gnjec, A; Fuller, SJ; Nolan, D; Gandy, SE; Martins, RN | Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer’s disease and cardiovascular disease | MOLECULAR PSYCHIATRY | 154 |
95 | 2006 | Yang, FJ; Vought, BW; Satterlee, JS; Walker, AK; Sun, ZYJ; Watts, JL; DeBeaumont, R; Saito, RM; Hyberts, SG; Yang, S; Macol, C; Iyer, L; Tjian, R; van den Heuvel, S; Hart, AC; Wagner, G; Naar, AM | An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis | NATURE | 152 |
96 | 2008 | Degoma, EM; Degoma, RL; Rader, DJ | Beyond high-density lipoprotein cholesterol levels – Evaluating high-density lipoprotein function as influenced by novel therapeutic approaches | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 151 |
96 | 2007 | Bradley, MN; Hong, C; Chen, MY; Joseph, SB; Wilpitz, DC; Wang, XP; Lusis, AJ; Collins, A; Hseuh, WA; Collins, JL; Tangirala, RK; Tontonoz, P | Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE | JOURNAL OF CLINICAL INVESTIGATION | 151 |
96 | 2006 | Ajayaghosh, A; Vijayakumar, C; Varghese, R; George, SJ | Cholesterol-aided supramolecular control over chromophore packing: Twisted and coiled helices | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 151 |
Table 2
Rank | Year | Authors | Title | Journal | Times cited |
with distinct optical, chiroptical, and morphological features | |||||
99 | 2008 | Erlund, I; Koli, R; Alfthan, G; Marniemi, J; Puukka, P; Mustonen, P; Mattila, P; Jula, A | Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol | AMERICAN JOURNAL OF CLINICAL NUTRITION | 150 |
99 | 2007 | Kodama, S; Tanaka, S; Saito, K; Shu, M; Sone, Y; Onitake, F; Suzuki, E; Shimano, H; Yamamoto, S; Kondo, K; Ohashi, Y; Yamada, N; Sone, H | Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol – A meta-analysis | ARCHIVES OF INTERNAL MEDICINE | 150 |
Table 3
Journal | Cholesterol and disease | Cholesterol metabolism/homeostasis | Cholesterol lowering drugs | Methods for measuring cholesterol | Cholesterol biochemistry/biophysics | Total articles |
NEW ENGLAND JOURNAL OF MEDICINE | 9 | 3 | 7 | 19 | ||
LANCET | 7 | 7 | 14 | |||
SCIENCE | 1 | 11 | 12 | |||
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 6 | 3 | 2 | 11 | ||
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1 | 5 | 6 | |||
CIRCULATION | 4 | 2 | 6 | |||
CLINICAL CHEMISTRY | 6 | 6 | ||||
BRITISH MEDICAL JOURNAL | 2 | 3 | 5 | |||
JOURNAL OF LIPID RESEARCH | 1 | 3 | 1 | 5 | ||
BIOCHIMICA ET BIOPHYSICA ACTA | 2 | 2 | 4 | |||
JOURNAL OF BIOLOGICAL CHEMISTRY | 3 | 1 | 4 | |||
AMERICAN JOURNAL OF CLINICAL NUTRITION | 3 | 3 | ||||
ANNUAL REVIEW OF BIOCHEMISTRY | 1 | 1 | 2 | |||
NATURE MEDICINE | 1 | 1 | 2 | |||
NATURE | 1 | 1 | 2 | |||
DIABETES CARE | 1 | 1 | 2 |
Table 3
Journal | Cholesterol and disease | Cholesterol metabolism/homeostasis | Cholesterol lowering drugs | Methods for measuring cholesterol | Cholesterol biochemistry/biophysics | Total articles |
CELL | 2 | 2 | ||||
ANNALS OF INTERNAL MEDICINE | 2 | 2 | ||||
MOLECULAR CELL | 1 | 1 | 2 | |||
JOURNAL OF CLINICAL INVESTIGATION | 1 | 1 | 2 | |||
ARCHIVES OF INTERNAL MEDICINE | 1 | 1 | ||||
METABOLISM | 1 | 1 | ||||
CLINICA CHIMICA ACTA | 1 | 1 | ||||
NATURE GENETICS | 1 | 1 | ||||
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1 | 1 | ||||
ANALYTICAL CHEMISTRY | 1 | 1 | ||||
BIOCHEMISTRY | 1 | 1 | ||||
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1 | 1 | ||||
JOURNAL OF ORGANIC CHEMISTRY | 1 | 1 | ||||
ZEITSCHRIFT FUR KLINISCHE CHEMIE UND KLINISCHE BIOCHEMIE | 1 | 1 | ||||
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1 | 1 | ||||
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1 | 1 |
This table shows the frequency distribution of the 100 most-cited papers of the last century by both research category (enumerated in the column headers) and journal (identified in the table rows). Each article was assigned one or two research categories.
Table 4
Journal | Cholesterol metabolism/homeostasis | Cholesterol and disease | Cholesterol lowering drugs | Cholesterol biochemistry/biophysics | Total articles |
LANCET | 2 | 10 | 9 | 21 | |
CIRCULATION | 4 | 6 | 3 | 13 | |
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1 | 3 | 5 | 9 | |
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 3 | 2 | 3 | 8 | |
NEW ENGLAND JOURNAL OF MEDICINE | 3 | 2 | 2 | 7 | |
JOURNAL OF CLINICAL INVESTIGATION | 4 | 1 | 1 | 6 | |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 3 | 2 | 5 | ||
CIRCULATION RESEARCH | 2 | 2 | 4 | ||
NATURE | 3 | 1 | 4 | ||
CELL METABOLISM | 2 | 2 | 4 | ||
JOURNAL OF LIPID RESEARCH | 3 | 1 | 4 | ||
NATURE GENETICS | 2 | 1 | 3 | ||
JOURNAL OF INTERNAL MEDICINE | 1 | 2 | 3 | ||
DIABETES CARE | 2 | 1 | 3 | ||
SCIENCE | 3 | 3 | |||
MOLECULAR PSYCHIATRY | 1 | 1 | 2 | ||
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2 | 2 | |||
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1 | 1 | 2 | ||
ARCHIVES OF INTERNAL MEDICINE | 1 | 1 | 2 | ||
EUROPEAN HEART JOURNAL | 1 | 1 | 2 | ||
JOURNAL OF HEPATOLOGY | 1 | 1 | 2 | ||
CURRENT OPINION IN LIPIDOLOGY | 1 | 1 | |||
AMERICAN JOURNAL OF HUMAN GENETICS | 1 | 1 | |||
DIABETES | 1 | 1 | |||
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1 | 1 |
Table 4
Journal | Cholesterol metabolism/homeostasis | Cholesterol and disease | Cholesterol lowering drugs | Cholesterol biochemistry/biophysics | Total articles |
PLOS ONE | 1 | 1 | |||
NATURE MEDICINE | 1 | 1 | |||
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1 | 1 | |||
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 1 | 1 | |||
HEPATOLOGY | 1 | 1 | |||
NEUROBIOLOGY OF DISEASE | 1 | 1 | |||
JOURNAL OF BIOLOGICAL CHEMISTRY | 1 | 1 | |||
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1 | 1 | |||
NATURE REVIEWS NEUROSCIENCE | 1 | 1 | |||
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 1 | 1 | |||
NEURON | 1 | 1 | |||
ANNUAL REVIEW OF PHYSIOLOGY | 1 | 1 | |||
PHARMACOLOGICAL REVIEWS | 1 | 1 | |||
BRITISH MEDICAL JOURNAL | 1 | 1 | |||
PLOS PATHOGENS | 1 | 1 | |||
STRUCTURE | 1 | 1 | |||
JOURNAL OF VIROLOGY | 1 | 1 | |||
JOURNAL OF NUTRITION | 1 | 1 | |||
CELL | 1 | 1 | |||
AMERICAN JOURNAL OF PATHOLOGY | 1 | 1 |
This table shows the frequency distribution of the 100 most-cited papers of the last decade by both research category (enumerated in the column headers) and journal (identified in the table rows). Each article was assigned one or two research categories.
4.Discussion
It is interesting to see the preponderance of different sub-disciplines in cholesterol research represented in Tables 1 and 2. In particular, the most cited articles over last 10 years shows a shift away from articles describing methods for the measurement of cholesterol towards (increasingly molecular) studies describing cholesterol metabolism/homeostasis, the role of cholesterol in diseases, and cholesterol-lowering drugs, compared with the most cited articles from the last 100 years. We hypothesize that the complete lack of the cholesterol measurement category in the top-100 list of the last decade, as can be seen in Table 4, indicates that while incremental improvements in this area have continued over the last ten years, there has been nothing which one could easily classify as a “quantum leap” producing a highly-cited landmark paper. By contrast, the papers cited in Table 2 suggest that the last 10 years have witnessed the advent of studies describing the role of cholesterol in non-cardiovascular diseases such as cancer (the second reference numbered 69) and Alzheimer’s (the second reference numbered 76 and 94). When comparing Tables 3 and 4, another salient feature is the dominance one observes in the most recent period of cardiovascular journals. By comparing the top-10 journals based on number of papers in each of the top-100 articles lists in Tables 3 and 4, one can observe past dominance of journals of a more general nature such as Clinical Chemistry, British Medical Journal, and Science being displaced through the introduction of the Journal of the American College of Cardiology and Circulation Research into the top ten. Also of note is that Circulation rose in the ranking from #6 to #2 when considering the most-cited papers of the last decade instead of the last century.
Some of the names in Table 1 will be clearly recognized by the majority of cholesterol research investigators as being “superstars”. For example the team of Michael S. Brown and Joseph L. Goldstein, who were awarded the 1985 Nobel prize for Physiology or Medicine 1985 for their work on the regulation of cholesterol metabolism, are jointly authors of nine papers in the most cited articles of the last century (Table 1, numbers 8, 18, 21, 23, 24, 45, 63, 67 and 69) and three from the most cited of the last 10 years (Table 2, numbers 65, 74 and the second reference numbered 87). Other names, especially in Table 2 are “rising stars” who, in the last decade, have made significant contributions to the cholesterol research literature.
Acknowledgements
The authors would like to thank the referees for their insightful comments.
References
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