Affiliations: Department of Foods and Nutrition, Purdue University,
West Lafayette, IN, USA | NOX Technologies, Inc., West Lafayette, IN, USA | NuSkin Enterprises and Pharmanex, Provo, UT, USA | Dermatology Consulting Services, High Point, NC,
USA | Department of Medicinal Chemistry and Molecular
Pharmacology, Purdue University, West Lafayette, IN, USA
Note: [] Address for correspondence: Dorothy M. Morré, Department of
Foods and Nutrition, Purdue University, 700 W. State St., West Lafayette, IN
47907-2059, USA. E-mail: morredm@purdue.edu
Abstract: ENOX proteins with an oscillatory pattern of production of
superoxide (measured by ferricytochrome c reduction) and with a period length
of 26 min increase linearity with age beginning at about 30 y to a maximum of
about age 60. The proteins are shed and appear in serum, saliva and urine.
Enhanced arNOX activity correlates with age and with oxidative changes
contributing to skin aging. Topical cosmetic preparations containing substances
that block arNOX activity are under evaluation to reduce visible symptoms of
skin aging.
DOI: 10.3233/BIO-2009-1077
Journal: BioFactors, vol. 34, no. 3, pp. 237-244, 2009
