Affiliations: Health Technology Research Center, National Institute
of Advanced Industrial Science & Technology, Ikeda,
Japan
Note: [] Address for correspondence: E. Niki, Health Technology Research
Center, AIST, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan. Tel.: +81 72
751 9991; Fax: +81 72 751 9964; E-mail: etsuo-niki@aist.go.jp
Abstract: Oxidative stress induced by reactive oxygen and nitrogen species has
been implicated in the pathogenesis of various disorders and diseases.
Biomarkers are needed for assessment of oxidative stress status in vivo
and also for health examination, diagnosis at early stage, prognosis, safe and
efficient drug development, and evaluation of efficacy of drugs, foods,
beverages, and supplements. Lipids are susceptible to oxidation and lipid
peroxidation products are potential biomarkers for oxidative stress status
in vivo and its related diseases. Recently, isoprostane, isoprostaglandin
homologues from arachidonic acid, neuroprostanes from docosahexaenoic acid,
hydroxyoctadecadienoic acid from linoleic acid, and oxysterols from cholesterol
have received much attention as potential biomarkers for oxidative stress
status in vivo. The physiological levels of these lipid peroxidation
products and potential application as biomarkers will be reviewed.
