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Article type: Research Article
Authors: Hamden, Khaled | Ayadi, Fatma | Jamoussi, Kamel | Masmoudi, Hatem | Elfeki, Abdelfattah
Affiliations: Animal Ecophysiology, Faculty of Sciences, Sfax, Tunisia | Biochemistry Laboratory, CHU Habib Bourguiba, Sfax, Tunisia | Immunology Laboratory, CHU Habib Bourguiba, Sfax, Tunisia
Note: [] Address for correspondence: Dr Khaled Hamden, Laboratory of Animal Ecophysiology, Faculty of Sciences, PB 802, 3018, Sfax; University of Sfax, Tunisia. Tel.: +216 97 469 111; Fax: +216 74 274 437; E-mail: khaled.hamden@yahoo.fr/ khalid.hamden@gmail.com
Abstract: In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan-induced diabetic rats was investigated. Diabetes was confirmed by measuring the glucoserua concentration 15 days after alloxan administration. Ajuga iva extract was administrated orally 3 weeks after alloxan injection. Our results investigate that Ajuga iva extract supplementation increased the levels of both enzymatic antioxidant (superoxide dismutase, catalase and gluthation peroxidase) and metals antioxidants (iron, copper, magnesium, calcuim) and decreased lipid peroxidation level (TBARs). Besides Ajuga iva ameliorated diabetes provoked hepatic and renal toxicity appeared by a lower level in total and direct bilirubin, urea, creatinine, triglyceride (TG), cholesterol and a higher level in HDL-cholesterol. Besides, the activities of phosphatase alkalines (PAL), aspartate and lactate transaminase (AST & ALT) were decreased. The benefices effects of phytoecdysteroids of Ajuga iva confirmed by histological observation in pancreatic tissues. In conclusion, Ajuga iva phytoecdysteroids supplements seem to be beneficial for correcting the hyperglycemia and preventing diabetic complications in liver, pancreas and kidneys.
Keywords: Ajuva iva, diabetes, toxicity, liver and kidney, histological changes, therapeutic and preventive effects
Journal: BioFactors, vol. 33, no. 3, pp. 165-175, 2008
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