Affiliations: Government Medical College / GND Hospital, Amritsar,
India
Note: [] Address for correspondence: Prof. Dr. Kumar Adarsh MD, DM,
FACC, 17F Beauty Avenue, Phase 2, Circular Road, Amritsar, Punjab, India. Tel.:
+91 183 2500707; Fax: +91 183 2500707; E-mail: adarshkumar_27@yahoo.com
Abstract: It is well known that by improving mitochondrial bioenergetics,
Coenzyme Q_{10} improves the systolic function in heart
failure. The aim of this study was to see whether it benefits the diastolic
dysfunction in hypertrophic cardiomyopathy (HCM) cases since diastolic
relaxation also requires energy like the systole. 200~mg/day of
CoQ_{10} was added to the conventional treatment in 46
patients with HCM diagnosed clinically and by echocardiography and by excluding
cases of long standing hypertension. A comparable group of 41 age/sex matched
cases received only conventional therapy. There was a significant improvement
in the parameters like NYHA class ⩾ 1, in quality of
life (QOL) on 6 minutes walk test, in diastolic dysfunction by ⩾
1 parameter and in MR ⩾ 1 grade. Post
treatment echocardiogram showed significant reduction in left ventricular
outflow tract (LVOT) gradient ⩾ 15 mm Hg in
obstructive cases (12 out of 46) in the treatment group. The mean
interventricular septal thickness (IVS) showed a 22.4% reduction (p <
0.005). The mean posterior wall thickness showed a 23.1% reduction (p <
0.005). No patient in the treatment Group had ventricular tachycardia (VT)
whereas 4 cases in the control group had VT. In both groups 1 patient was lost
due to sudden cardiac death (SCD).
Keywords: Coenzyme Q[TeX:] _{10}, HCM, diastolic dysfunction, energy
Journal: BioFactors, vol. 32, no. 1-4, pp. 145-149, 2008
