Affiliations: School of Pharmacy, Fourth Military Medical
University, Xi'an, China | Xijing Hospital, Fourth Military Medical University,
Xi'an, China | College of Stomatology, Fourth Military Medical
University, Xi'an, China
Abstract: The aim of this study was to prepare konjac glucomannan
(KGM)/chitosan (CS) film containing glycidyl methacrylate derivatized dextran
(dex-GMA)/acrylic acid(AAc) nanoparticles loaded with antibacterial agent. In
this study, An optimized procedure chosen from three methods was used to
prepare Erythromycin (EM)-loaded poly(dex-GMA/AAc) nanoparticles and obtained
nanoparticles ranged from 50–200 nm. Film was found to have equilibrium water
content (EWC) 99.3% which could prevent exudates on wound bed from
accumulating and also have excellent water adsorption 2362.3 ± 55.2%;
the water vapor transmission rate (WVTR) was 2335 ± 36 gm^{-2}day^{-1}
and evaporative water loss from the film (EWL) was approximately 10% after
1 h and within 6 h it increased to 90%. Drug release of film containing
nanoparticles or absent was determined, within 22 h accumulative release was
40.3%, 72.5% respectively. In conclusion, KGM/CS film containing
nanoparticles could not only maintain a moist environment over wound bed in
moderate to heavily exuding wound but also provide a continuous and sustained
release of the antibacterial agent on the wound surface, which could be
potential wound dressing.
