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Article type: Research Article
Authors: Murad, Leonardo Borges | Guimarães, Marcela Rodrigues Moreira | Vianna, Lucia Marques
Affiliations: Laboratory of Nutritional Investigation and Degenerative-Chronic Diseases, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro (City), Brazil
Note: [] Address for correspondence: L.M. Vianna, Universidade Federal do Estado do Rio de Janeiro – Laboratório de Investigação em Nutrição e Doenças Crônico-Degenerativas-UNIRIO, Rua Xavier Sigaud, 290 – Térreo, Urca. Zip code 22290-240, Rio de Janeiro City, Rio de Janeiro State, Brazil. E-mail: lindcd@ig.com.br
Abstract: Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effect in vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n=6, each). The treated group received 10 mg/Kg^{-}/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p<0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.
Keywords: Decylubiquinone, systolic blood pressure, oxidative stress, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglycerides, malondialdehyde, blood glucose levels, SHRSP
Journal: BioFactors, vol. 30, no. 1, pp. 13-18, 2007
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