Croton lobatus, an African medicinal plant: Spectroscopic and chemical elucidation of its many constituents

Issue title: Free Radicals in Biology and Medicine: From Inflammation to Biotechnology

Article type: Research Article

Authors: Chabert, Philippe | Attioua, Barthélemy | Brouillard, Raymond

Affiliations: Laboratoire de Chimie des Polyphénols, Université Strasbourg I, Faculté de Chimie, CNRS, UMR 7177,1, rue Blaise Pascal, 67000 Strasbourg, France

Note: [] Address for correspondence: Raymond Brouillard, Laboratoire de Chimie des Polyphénols, Université Strasbourg I, Faculté de Chimie, CNRS, UMR 7177, 1, rue Blaise Pascal, 67000 Strasbourg, France. Tel.: +33 390 241 342; Fax: +33 390 241 341; E-mail: brouil@chimie.u-strasbg.fr

Abstract: The chemical constituents of the African medicinal plant Croton lobatus were elucidated and characterised using 1D and 2D-NMR analysis and the application of the technique of High Resolution Electron Ionization Mass Spectrometry (HREIMS) and High Resolution Mass Spectrometry (HRMS). The novel triglyceride lobaceride or 3-((6Z,9Z)dodeca-6,9-dienoyloxy)-2-octanoyloxypropyl (6Z,9Z)dodeca-6,9-dienoate, along with ten compounds were isolated from the stems and leaves of Croton lobatus.

Keywords: Croton lobatus, euphorbiaceae, structure elucidation, sterol, diterpene, triterpene, nitrogen compound, carboxylic ester, cinnamic acid derivative, malaria

Journal: BioFactors, vol. 27, no. 1-4, pp. 69-78, 2006