Affiliations: Division of Environmental Technology, Aomori
Industrial Research Center, 4-11-6 Daini-tonyamachi, Aomori 030-0113,
Japan | Onodera Brewhouse Co., 39 Zaifukojimachi, Sannohe
Town, Aomori 039-0132, Japan | Aomori University of Health and Welfare, 58-1 Mase,
Aomori 030-8505, Japan
Abstract: The fruit of Viburnum dilatatum Thunb, called gamazumi in
Japan, showed the strong antioxidant activities, and its preventive effects on
oxidative stress and active ingredients were investigated. Male rats were
subjected to water immersion restraint stress for 6 hours, after ingestion of
the gamazumi crude extract (GCE) for 2 weeks. The formation of gastric ulcer
was reduced, and the lipid peroxidation in plasma and organs also lowered in
rats ingested GCE. In the streptozotocin-induced diabetic rats given GCE for 10
weeks, inhibition of lipid peroxidation in plasma, erythrocytes and organs was
observed, and the increase of plasma glucose level also lowered. On the other
hand, two cyanidin glycosides, two chlorogenic acids and quercetin were
identified, and especially cyanidin 3-sambubioside (Cy 3-sam) showed the strong
radical scavenging activity. It is suggested that Cy 3-sam is a key compound
contributing to the physiological effects of V. dilatatum fruit.
