Antihypertensive effect of γ-amino butyric acid enriched soy products in spontaneously hypertensive rats

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Shizuka, F. | Kido, Y. | Nakazawa, T. | Kitajima, H. | Aizawa, C. | Kayamura, H. | Ichijo, N.

Affiliations: Department of Living Sciences, Nagano Prefectural College, 8-49-7 Miwa, Nagano-City, 380-8525, Japan. Tel.: +81 26 234 1221; Fax: +81 26 235 0026; E-mail: fujikos@sonata.plala.or.jp | Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Kyoto, Japan | Marukome Co. Ltd., Nagano, Japan

Note: [] Corresponding author

Abstract: The effect of γ-amino butyric acid (GABA)-enriched soybean on blood pressure was investigated in male spontaneously hypertensive rats. Ten-week-old rats were given diets containing graded levels of GABA-enriched soybean powder for 8 weeks. The systolic blood pressure in rats fed 0.15% GABA diet was significantly lower at 1st week and maintained lower values for 4 weeks as compared with 0% GABA controls. No effect on blood pressure was found in those of 0.03 and 0.3% GABA. The results suggest that there exist appropriate dietary GABA level to get the blood pressure lowering effect.

Keywords: γ-Amino butyric acid, soybean, blood pressure, spontaneously hypertensive rats

Journal: BioFactors, vol. 22, no. 1-4, pp. 165-167, 2004