Affiliations: National Agricultural Research Center, 1-3-1
Senyu-cho, Zentsuji-shi, Kagawa, 765-8508, Japan. Tel.: +81 877 63 8129; Fax:
+81 877 63 1683; E-mail: ksekiya@affrc.go.jp | Research Insutitute, Fuji sangyo Co.Ltd
Note: [] Corresponding author
Abstract: Antidiabetic and hypoglycemic drugs have been reported to enhance
adipocyte differentiation of 3T3-L1 preadipocytes. We previously reported that
ginseng (active constituents: ginsenosides) enhanced the differentiation [1].
In this experiment, effect of some ginger group food extracts on the adipocyte
differentiation was investigated using cultured mouse 3T3-L1 preadipocytes.
3T3-L1 cells were grown as monolayer cultures at 37°C in DMEM supplemented
by 10% FBS under the atmosphere of 5% CO_2–95% air.
Ginger extracts were found to enhance the adipocyte differentiation. Active
constituent was purified and identified as gingerol. In the gingerol-treated
cells, insulin-sensitive glucose uptake was increased. It is expected that
ginger enhance the insulin-sensitivity, and improve chronic disease, such as
diabetes.
