Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Kwon, Ki Han | Murakami, Akira | Tanaka, Takuji | Ohigashi, Hajime

Affiliations: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan | First Department of Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan

Note: [] Corresponding author. Tel.: +81 75 753 6281; Fax: +81 75 753 6284; E-mail: ohigashi@kais.kyoto-u.ac.jp

Abstract: Oxidative stress has been shown to play pivotal roles in the onset of inflammatory bowel disease. We evaluated the effects of a dietary anti-oxidant, Antioxidant Biofactor (AOB®), a processed grain food, on dextran sulfate sodium (DSS)-induced colitis in mice. Female ICR mice were fed a diet containing 0.1% or 1% AOB for 2 weeks, during which they were given 5% DSS in drinking water for the latter 1 week to induce colitis. A diet containing 1% AOB, but not that with 0.1% AOB, attenuated DSS-induced body weight loss and colon shortening (each, P < 0.05), and dramatically improved colitis histologic scores. In addition, DSS-induced increases in colonic mucosal IL-1β, but not TNF-α, protein levels were significantly abrogated in 1% AOB-fed mice (P < 0.05). Further, 1% dietary AOB abolished the expression of IL-1β mRNA levels in colonic mucosa (P < 0.01). Our results suggest that AOB is effective for the prevention of DSS-induced colitis in mice.

Keywords: antioxidant, dextran sulfate sodium, experimental colitis, oxidative stress

Journal: BioFactors, vol. 21, no. 1-4, pp. 179-184, 2001