Affiliations: Department of Bioscience and Biotechnology, Faculty of
Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581,
Japan. E-mail: tatibana@agr.kyushu-u.ac.jp
Note: [] Corresponding author
Abstract: High-affinity IgE receptor FcεRI is key
molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate
(EGCG) has a suppressive effect of the expression of the
FcεRI. We show here that EGCG highly associates
with plasma membrane microdomains, lipid rafts. The disruption of these lipid
rafts caused a reduction of the amount of raft-associated EGCG and the
FcεRI -suppressive effect of EGCG. These results
suggest that the interaction between EGCG and the lipid rafts is important for
EGCG's ability to downregulate FcεRI
expression.
