Affiliations: POLA Laboratories, POLA Chemical Industries, Inc., 560
Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan. Tel.: +81 45 826 7245; Fax:
+81 45 826 7239; E-mail: t-fukuda@pola.co.jp | Faculty of Pharmaceutical Sciences, Okayama
University, Tsushima, Okayama 700-8530, Japan
Note: [] Corresponding author
Abstract: We examined the in vivo antioxidative effect of a polyphenol-rich
walnut extract on oxidative stress in mice with type 2 diabetes.
C57BL/KsJ-db/db mice were used as an accelerated oxidative animal model. The
oral administration of the walnut polyphenol fraction at 200~mg/kg body weight
for 4 weeks caused a significant decrease in the level of urinary
8-hydroxy-2'-deoxyguanosin, which is an in vivo marker of oxidative stress.
These results imply that walnut polyphenols have both in vitro and in vivo
antioxidant effects.
