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Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)
Article type: Research Article
Authors: Suzuki, Rikako; | Kohno, Hiroyuki | Murakami, Akira | Koshimizu, Koichi | Ohigashi, Hajime | Yano, Masamichi | Tokuda, Harukuni | Nishino, Hoyoku | Tanaka, Takuji
Affiliations: The First Department of Pathology, Kanazawa Medical University, Ishikawa 920-0293, Japan | Research Fellow of the Japan Society for the Promotion of Science, Tokyo 102-8471, Japan | Division of Applied Life Science, Graduate School of Agriculture, Kyoto University, Kyoto 606-0085, Japan | National Institute of Fruit Tree Science, Shizuoka 424-0292, Japan | Department of Biochemistry, Kyoto Prefecture University of Medicine, Kyoto 602-0841, Japan
Note: [] Address for correspondence: Dr. Rikako Suzuki, The First Department of Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. Tel.: +81 76 286 2211; Fax: +81 76 286 6926; E-mail: rikako@kanazawa-med.ac.jp
Abstract: The inhibitory effects of dietary feeding of citrus nobiletin on azoxymethane (AOM)-induced rat colon carcinogenesis using a long-term bioassay were investigated. Five-week old male F344 rats were initiated with two weekly subcutaneous injections of AOM (20 mg/kg bw) to induce colonic tumors. They were also given the diets containing 0.01% or 0.05% nobiletin for 34 weeks, starting one week after the last dosing of AOM. At the end of the study, the incidence of colonic adenocarcinoma were 67% in the AOM alone group, 55% in the AOM→0.01% nobiletin group, 35% (p < 0.05) in the AOM→0.05% nobiletin group. Also, nobiletin feeding reduced the cell-proliferation activity, increased the apoptotic index, and decreased the prostaglandin E_{2} content in colonic adenocarcinoma and/or colonic mucosa. These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis.
Keywords: nobiletin, inhibition, colon carcinogenesis, rats
Journal: BioFactors, vol. 21, no. 1-4, pp. 111-114, 2004
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