Affiliations: College of Pharmacy, Seoul National University,
Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea. Tel.: +82 2 880 7845;
Fax: +82 2 874 9775; E-mail: surh@plaza.snu.ac.kr | Sungkyunkwan University School of Medicine, Seoul
110-102, South Korea
Note: [] Corresponding author
Abstract: Chemoprevention refers to the use of nontoxic chemical substances to
inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from
edible plants have been reported to interfere with a specific stage of the
carcinogenic process. Some anti-inflammatory phytochemicals with
cyclooxygenase-2 inhibitory activity have been found to exert chemopreventive
properties by targeting intracellular signaling molecules (recently reviewed by
Y.-J. Surh, Nature Reviews Cancer, 3: 768–780, 2003). These include
mitogen-activated protein kinases and transcription factors, such as
NF-κB and AP-1.
