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Issue title: The Third Conference of the International CoQ10 Association
Article type: Research Article
Authors: Battino, M. | Giunta, S. | Galeazzi, L. | Galeazzi, R. | Mosca, F. | Santolini, C. | Principi, F. | Ferretti, G. | Bacchetti, T. | Bencivenga, R. | Piani, M. | Riganello, G. | Littarru, G.P.
Affiliations: Institute of Biochemistry, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy | Central Analysis Laboratory, INRCA Hospital, Via Montagnola, Ancona, Italy | Blood Center, Umberto I Hospital, Ancona, Italy
Note: [] Address for correspondence: Prof. Gian Paolo Littarru, Institute of Biochemistry, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri, 65, 60131 Ancona, Italy. Tel.: +39 071 2204674; Fax: +39 071 2801932; E-mail: littarru@univpm.it
Abstract: The aim of this study was to inquire the antioxidant status in plasma and lipoproteins isolated from normal subjects possessing different ApoE genotypes. For this purpose we investigated blood samples from 106 healthy blood donors: the distribution of ApoE alleles (E2/E2 = 0.9%, E2/E3 = 10.4%, E2/E4 = 2.8%, E3/E3 = 71.7%, E3/E4 = 12.3% and E4/E4 1.9% with 1, 11, 3, 76, 13, and 2 subjects respectively for each genotype) was in agreement with previous data. Almost no differences were found in the concentrations of both coenzyme Q_{10} (CoQ_{10}) and vitamin E for the different genotypes. Concentration of CoQ_{10} in isolated lipoproteins was also similar, in the different genotypes, when referred to cholesterol; CoQ_{10} in LDL was higher for the E3/E3 subjects when referred to protein. Neither CoQ_{10} nor vitamin E correlated with paraoxonase (PON) activity or cholesteryl-ester hydroperoxides (CHP). Furthermore, there was no correlation between the same lipophilic antioxidants and CHP levels. The only E2 homozygous subject found had high levels of PON and low levels of CHP; the two E4/E4 subjects had low PON activity together with low levels of CHP.
Keywords: Vitamin E, LDL, HDL, paraoxonase, cholesteryl-esters hydroperoxide
Journal: BioFactors, vol. 18, no. 1-4, pp. 299-305, 2003
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